COSAM » COSAM Faculty » Physics (ARCHIVED) » Michael Gramlich

Michael Gramlich
Assistant Professor

Research Areas: Biophysics, Neuroscience, Microscopy

Office: Leach Science Center 3114

380 Duncan Drive
Auburn, AL 36849




University of Missouri - Columbia, Ph.D.
University of Missouri - Columbia, B.S.

Professional Employment

Auburn University, Department of Physics, Assistant Professor
Postdoctoral Researcher, Washington University in St. Louis School of Medicine
Postdoctoral Researcher, University of Massachusetts - Amherst

Research and Teaching Interests

My lab focuses on the principles that regulate intra-cellular transport of neuronal resource sharing. First, how do resources, such as synaptic vesicles, navigate the complex road system that supports neurons? There are many road-blocks or defects that inhibit transport, and resources must navigate them quickly. Second, how are resources directed to synapses that need them? Synapses are activated when they communicate with other neurons, and need more resources than non-activated synapses. Third, how do synapses capture and utilize the resources they need? Resources travel quickly to synapses that need them, but must still be captured by synapses before use.

Selected Publications

1.      rTg (TauP301L) 4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular

          E. Taipala, J.C. Pfitzer, M. Hellums, M.N. Reed, M.W. Gramlich, Front Synaptic Neurosci., 14:925546



2.      Myosin V regulates spatial localization of different forms of neurotransmitter release in central synapses

         D Maschi, MW Gramlich, VA Klyachko Frontiers in Synaptic Neuroscience 13, 650334


3.      Distinguishing synaptic vesicle precursor navigation of microtubule ends with a single rate constant model

         MW Gramlich, S Balseiro-Gómez, SMA Tabei, M Parkes, S Yogev, Scientific reports 11 (1), 1-11


4.       Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

          D Maschi, M Gramlich, V Klyachko, eLife 7, e39440


5.       Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons

           MW Gramlich, VA Klyachko, Cell Reports 18 (9), 2096–2104


6.       Single molecule investigation of kinesin-1 motility using engineered microtubule defects

           MW Gramlich, L Conway, WH Liang, JA Labastide, SJ King, J Xu, JL Ross, Scientific Reports 7, 44290


7.       Activity-Dependence of Synaptic Vesicle Dynamics

          KVA Forte LA, Gramlich MW, J Neuroscience


8.       Fluorescence imaging of nanoscale domains in polymer blends using stochastic optical reconstruction microscopy (STORM)

          MW Gramlich, J Bae, RC Hayward, JL Ross, Optics express 22 (7), 8438-8450


9.       Modern methods to interrogate microtubule dynamics

          M Bailey, L Conway, MW Gramlich, TL Hawkins, JL Ross, Integrative Biology 5 (11), 1324-1333


10.       Microtubule orientation and spacing within bundles is critical for long‐range kinesin‐1 motility

          L Conway, MW Gramlich, SM Ali Tabei, JL Ross, Cytoskeleton 71 (11), 595-610


Last updated: 11/27/2023