COSAM » Events » 2021 » April » DMS Statistics and Data Science Seminar

DMS Statistics and Data Science Seminar
Time: Apr 01, 2021 (02:00 PM)
Location: ZOOM


Speaker: Dave Zhao (Associate Professor in Statistics, University of Illinois at Urbana-Champaign) 

Title: Perfect is the enemy of good: New shrinkage estimators for genomics


Abstract: Simultaneous estimation problems have a long history in statistics and have become especially common and important in genomics research: modern technologies can simultaneously assay tens of thousands to even millions of genomic features that can each introduce an unknown parameter of interest. These applications reveal some conceptual and methodological gaps in the standard empirical Bayes approach to simultaneous estimation. This talk summarizes standard approaches, illustrates some difficulties, and introduces an alternative approach based on regression modeling, and illustrates some new estimators that can be applied to gene expression denoising, coexpression network reconstruction, and large-scale gene expression imputation.



Last updated: 03/29/2021