My research interests lie in the interaction of engineered nanoparticles (NPs) with biological systems. Over the past decade, nanotechnology has evolved from fundamentals to applications. Since NPs have great potential to bring improvements to the biomedical field and have become part of a myriad of consumer goods, from food packaging and beverages to cosmetics, their impact on biological systems should be better understood. Cell and molecular biology tools (including Omics-based approaches) are employed to detect molecular changes and perturbations in biological networks and pathways by NPs, which may lead to potential adverse effects on human health.

1. Falagan-Lotsch, P.*, Murphy, C. J.* (2020) Network-based Analysis Implies Critical Roles of microRNAs in the Long-Term Cellular Responses to Gold Nanoparticles. Nanoscale 12: 21172-21187.

2. Murphy, C. J., Chang, H. H., Falagan-Lotsch, P., Gole, M. T., Hofmann, D. M., Hoang, K. N. L., McClain, S. M., Meyer, S. M., Turner, J. T., Unnikrishnan, M., Wu, M., Zhang, X., Zhang, Y. (2019) Virus-Sized Gold Nanorods: Plasmonic Particles for Biology. Accounts of Chemical Research 52 (8): 2124-2135.

3. Falagan-Lotsch, P.*, Grzincic, E. M., Murphy, C. J.* (2017) New Advances in Nanotechnology-Based Diagnosis and Therapeutics for Breast Cancer: An Assessment of Active-Targeting Inorganic Nanoplatforms. Bioconjugation Chemistry 28(1):135-152.

4. Luz, C. M., Boyles, M. S. P., Falagan-Lotsch, P., Pereira, M. R., Tutumi, H. R., Santos, E. O., Martins, N. B., Himly, M., Sommer, A., Foissner, I., Duschl, A., Granjeiro, J. M., Leite, P. E. C. (2017) Poly-Lactic Acid Nanoparticles (PLA-NP) Promote Physiological Modifications in Lung Epithelial Cells and are Internalized by Clathrin-Coated Pits and Lipid Rafts. Journal of Nanobiotechnology 15:

5. Ribeiro, A. R., Leite, P. E., Falagan-Lotsch, P., Benetti, F., Micheletti, C., Budtz, H. C., Jacobsen, N. R., Lisboa-Filho, P. N., Rocha, L. A., Kühnel, D., Hristozov, D., Granjeiro, J. M. (2017) Challenges on the toxicological predictions of engineered nanoparticles. NanoImpact 8: 59-72.

6. Falagan-Lotsch, P., Grzincic, E. M., Murphy, C. J. (2016) One Low-Dose Exposure of Gold Nanoparticles Induces Long-Term Changes in Human Cells. Proceedings of the National Academy of Sciences 113 (47): 13318−

7. Grzincic, E. M., Yang, J. A., Drnevich, J., Falagan-Lotsch, P.*, Murphy, C. J.* (2015) Global Transcriptomic Analysis of Model Human Cell Lines Exposed to Surface-Modified Gold Nanoparticles: The Effect of Surface Chemistry. Nanoscale 7: 1349-1362.

*Corresponding author

Google Scholar Page