Click name to see page Return to Biological Sciences Biosciences Faculty Armbruster, Jonathan Barbaree, James Best, Troy L. Bowling, Scott A. Boyd, Robert Bradley, James T. Brown, Alfred Chadwick, Nanette E. Cobine, Paul Dobson, F. Stephen Dute, Roland Feminella, Jack W. Fielman, Kevin Folkerts, Debbie R. Folkerts, George W. Goertzen, Leslie Guyer, Craig Halanych, Ken Henry, Raymond P. Hill, Geoffrey E. Hood, Wendy R. Jacobsen, Shawn Kearley, Matthew Kempf, Stephen C. Liles, Mark R. Lishak, Robert S. Locy, Bob McVay, Catherine Mendonca, Mary T. Miller, Michael E. Moss, Anthony G. Person, Davonya Rashotte, Aaron Roberts, Sharon Santos, Scott R. Silo-Suh, Laura Singh, Narendra Suh, Sang-Jin Sundermann, Christine A. Wit, Lawrence C. Wooten, Marie W. Wooten, Michael C. Wysocka-Diller, Joanna

Paul Cobine, Ph.D., Assistant Professor

Office Location:  325 Rouse Life Sciences Building Mailing Address: Biological Sciences 101 Rouse Life Sciences Auburn University, AL, 36849 Tel: (334) 844-1661 pac0006@auburn.edu

Education
2007- Postdoctoral Fellow, University of Utah
2002- The University of Queensland, Australia, Ph.D., Microbiology
1996- The University of Queensland, Australia, B.S., Microbiology

Research & Teaching Interests
My research is focused on the mechanisms for the recruitment of metals into mitochondria and their subsequent insertion, as cofactors, into the multi-subunit complexes of the electron transport chain. The majority of the studies use the model organism Saccharomyces cerevisiae with a combination of protein chemistry and genetics. Mitochondrial dysfunction is a common element of most human disease, so insight gleaned from the assembly process in yeast is crucial to understanding many pathophysiological states. I teach the fundamentals of microbiology in BIOL 3200 General Microbiology.

Recent Publications

F. Pierrel, O. Khalimonchuk, P.A. Cobine, M. Bestwick and D.R. Winge (2008) “Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis facilitating the maturation of Cox1” Mol. Cell. Biol., 28:4927-39.

K.M. Rigby, P.A. Cobine, O. Khalimonchuk and D.R. Winge (2008) “Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis” J. Biol. Chem., 283: 15015-15022.

F. Pierrel, M. L. Bestwick, P.A. Cobine, O.Khalimonchuk, J.A. Cricco and D.R. Winge (2007) “Coa1 links Mss51 post-translational function to cofactor insertion in cytochrome c oxidase assembly” EMBO J., 26: 4335–4346.

S.C. Leary, P.A. Cobine, B.A. Kaufman, G. Guercin, A.Mattman, J. Palaty, G. Lockitch, D.R. Winge, P. Rustin, R. Horvath, and E. A. Shoubridge (2007) “The human cytochrome c oxidase assembly factors SCO1 and SCO2 have additional roles in the regulation of cellular copper homeostasis.” Cell Metab., 5: 9-20.

P.A. Cobine, F. Pierrel, M.L. Bestwick and D.R. Winge (2006) “Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.” J. Biol. Chem., 281: 36552-9.

M. Yang, P.A. Cobine, A. Naranuntarat, S. Molik, R. Lill, D.R. Winge and V.C. Culotta (2006) “The effects of mitochondrial iron homeostasis on co-factor specificity of superoxide dismutase 2” EMBO J., 25: 1775-83.
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P.A. Cobine, F. Pierrel, S.C. Leary, F. Sasarman, Y-C. Horng, E.A. Shoubridge and D.R. Winge (2006) “The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding” J. Biol. Chem., 281: 12270-6.

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