Harrison School of Pharmacy

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Subhrajit Bhattacharya headshot

Subhrajit Bhattacharya

Assistant Research Professor
Department: Drug Discovery and Development
Auburn University
Harrison School of Pharmacy
117 Pharmacy Research Building
720 South Donahue Drive
Auburn, AL 36849
Email: szb0050@auburn.edu
Phone: 334-844-8350


Research Information [PDF]

Bio

Education:
  • B.Pharm. - Institute of Pharmacy (India), (2009)
  • M.S., Pharmaceutical Sciences - Butler University (2011)
  • Ph.D., Pharmaceutical Sciences - Auburn University (2015)

Dr. Subhrajit Bhattacharya joined the Harrison School of Pharmacy faculty on March 2, 2020 as an assistant research professor. In his position, Dr. Bhattacharya will conduct cutting-edge research in neuroscience, electrophysiology, using modern technology and genetic models, guide new researchers towards accomplishing their research goals, and supervise the Electrophysiology and Neuroscience Core in the Pharmacy Research Building.

Dr. Bhattacharya received his bachelor of pharmacy degree from the Institute of Pharmacy in Jalpaiguri, West Bengal, India in 2009. He then completed his master of science degree in pharmaceutical sciences from Butler University in 2011.

His initial stint at Auburn came as a graduate student, working under Dr. Vishnu Suppiramaniam. Dr. Bhattacharya completed his Ph.D. in pharmaceutical sciences in 2015. He then went on to complete a postdoctoral fellowship in neuroscience at Emory University, working under Drs. Stephen Traynelis and Ray Dingledine.

Dr. Bhattacharya is an active member of the Society for Neuroscience and the American Epilepsy Society. He was the recipient of an AES Fellowship in 2018-19.

Dr. Bhattacharya currently lives in Newnan with his family. In his spare time, he enjoys swimming, riding bicycles, going for long drives, and traveling.


Research Interests

Dr. Bhattacharya's lab uses a wide range of electrophysiological techniques to probe the function of neuronal circuits, and synapses, including voltage clamp recordings from neurons responding to electrical or optical activation of identified afferent inputs, whole cell currents from native and recombinant receptors, recordings from receptors incorporated into lipid bi-layers, and excised outside-out patches that contain a single active channel (in epilepsy, stroke, prenatal use of substances of abuse, AD, and neurodegeneration).

He investigates questions relating to circuit function in healthy tissue and in neurological disease, synaptic transmission, and ion channel modulation. Two simultaneous approaches revolve around the screening of new pharmacological probes for modulating glutamate receptors through chemical biology, and the evaluation epileptic phenotypes and genotypes on circuit function.

In addition to electrophysiology, he uses modern molecular approaches, cutting edge imaging, and biochemical analyses to evaluate receptor, synaptic, and circuit function.


Publications

Google Scholar | PubMed

  • Bhattacharya S, Roy Pradhan S, Khandaker S, Chowdhury S, (2010) Quantitative Structure Activity Relationship Study of Some Flavonoids by Fujita-Ban Method, International Journal of Research in Pharmaceutical and Biomedical Sciences
  • Parameshwaran K, Buabeid MA, Bhattacharya S, Uthayathas S, Kariharan T, Dhanasekaran M, Suppiramaniam V, (2013) Long Term Alterations in Synaptic Physiology, Expression of β2 Nicotinic Receptors and ERK1/2 Signaling in the Hippocampus of Rats with Prenatal Nicotine Exposure, Neurobiol Learn Mem
  • Bloemer J, Bhattacharya S, Amin R, Suppiramaniam V, (2014) Impaired Insulin Signaling and Mechanisms of Memory Loss, Progress in Molecular Biology and Translational Science
  • Suppiramaniam V, Bloemer J, Reed M and Bhattacharya S, (2016) Neurotransmitter Receptors. Comprehensive Toxicology 3rd Edition, 2016-2017, Oxford Academic Press
  • Bhattacharya S, Suppiramaniam V et al., (2016) Altered AMPA Receptor Expression Plays an    Important Role in Inducing Bidirectional Synaptic Plasticity During Contextual Fear Memory Reconsolidation, Neurobiol Learn Mem
  • Swanger SA, Bhattacharya S, Traynelis SF, Yuan H, et al., (2016) Mechanistic Insight into Receptor Dysregulation by Disease-associated Rare Variants in the GluN2A and GluN2B Agonist Binding Domains, American Journal of Human Genetics, Cell Press
  • Ogden KK, Bhattacharya S, Traynelis SF, Yuan H, et al., (2016) Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology, PLOS Genetics
  • Kaiser TM, Bhattacharya S, Traynelis SF and Burger PB, et al., (2017) The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor, Molecular Pharmacology
  • Bhattacharya S, (2017) Understanding Memory Reconsolidation, Journal of Cognitive Neuropsychology
  • Bhattacharya S, Ma Y, Dunn AR, Bradner JM, Scimemi A, Miller GW, Wichmann T, Traynelis SF, (2018), NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate, Journal of neuroscience research
  • Bhattacharya S, Khatri AK, Swanger SA, DiRaddo JO, Yi F, Hansen KB, Yuan H, Traynelis SF, (2018) Triheteromeric GluN1/GluN2A/GluN2C NMDARs with unique single channel properties are the dominant receptor population in cerebellar granule cells, Neuron
  • Maitra S, Bhattacharya D, Das S, Bhattacharya S, (2018) Melatonin and its anti-glioma functions: a comprehensive review, Reviews in the Neurosciences
  • Bhattacharya S and Traynelis SF, (2018) Unique biology and single channel properties of GluN2A- and GluN2C-containing triheteromeric NMDA receptors, Journal of Experimental Neuroscience
  • Maitra S, De A, Das B, Roy SN, Chakraborty R, Samanta A, Bhattacharya S, (2019)
  • Seasonal variation of phyto-constituents of tea leaves affects anti-proliferative potential, Journal of the American College of Nutrition
  • Wei WX, Bhattacharya S,  … Poduri A, Aizenman E, Traynelis SF, et al., (2019) Heterogeneous Clinical and Functional Features of GRIN2D-related Developmental and Epileptic Encephalopathy, Brain
  • Yi F, Bhattacharya S, Thompson CM, Traynelis SF, and Hansen KB, (2019) Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors, J Physiology

Last Updated: March 30, 2020