Harrison School of Pharmacy
Graduate Student Directory
Degree: M.S., Pharmaceutical Science
Degree Option: Medicinal Chemistry
Anticipated Completion: 2017
Advisor: Angela Calderon
Thankhoe Rants’o's research interests are in natural product discovery, starting from plant extraction up to identification and isolation of a bioactive molecule. He is actively screening plant extracts for TB, malaria and cancer bioactivities using LC-MS functional enzymatic assays on isolated targets. To address a common discrepancy between in vitro and in vivo models, he is ambitiously determining pharmacokinetic properties of bioactive molecules.
Rants'o is also interested in drug-botanical pharmacokinetic interactions. He is determining these in the chemotherapeutic treatment of cancer where complementary and alternative medicines (or botanical dietary supplements) are commonly used together with prescribed drugs. His main focus is identifying botanical constituents that are bioavailable and have potential to inhibit or induce CYP3A4 metabolizing enzyme.
Last Updated: March 9, 2017