The Striegler Lab - Research
The Striegler Lab
College of Science and Mathematics

The Striegler Lab

Home
Research
Principal Investigator
Lab Members
Teaching
Publications
Outreach
News
Resources


Dept. of Chem. & Biochem.
COSAM
Auburn University
Visitor Information

Dr. Susanne Striegler
Associate Professor
Dept. of Chem. & Biochem.
368 Chemistry Building
Auburn University
Auburn, AL 36849-5312
U.S.A.
Phone: ++1 (334) 844 6954
FAX: ++1 (334) 844 6959
Email: Please follow the link

Last edit: Wednesday, 05-Oct-2011 09:15:07 CDT

Advanced Materials based on Molecular Recognition

 
The development of functional enzyme mimics is of great current interest, and some remarkable achievements have been made recently. The mimicking of sugar-transforming enzymes by chemical models is not accomplished yet and achievements in this area are pending. Particularly promising in that regards are polymeric catalysts with submicron size that use their overall macromolecular structure to facilitate catalytic turnovers.

Our recent research efforts are focused on the synthesis and design of functional enzyme models based on molecular recognition between immobilized metal complexes and biomolecules, particularly carbohydrates. We focus on the catalytic synthesis of unnatural sugars that might find use in treating obesity or in enabling an increased oral availability of new glycosylated pharmaceuticals. Last, the metal complexes involved show carbohydrate differentiation ability, cytotoxicity and antiviral activity that might provide new treatment options for cancer and/or the human immunodeficiency virus (HIV).


In short, our research is currently directed into the following areas:
  • Design and synthesis of new ligands to support catalysts in green solvents like water
  • Synthesis of new functionalized glycosides and their enzymatic evaluation as transition state analogs
  • Investigation of the binding events between metal complexes and biomolecules
  • Study of catalytic turnover of biomolecules promoted by transition metal complexes
  • Development of advanced materials that perform unnatural reactions enzyme-like
Footer

Valid HTML 4.01! Valid CSS!

http://www.auburn.edu/~striesu/research.html, © 2006 by S. Striegler

Last modified: Wednesday, October 05, 2011 by Webmaster