MED. CHEM. I STUDY GUIDE
Quiz One

1. Life Cycle of a Chemical Neurotransmitter (CNT)

Step 1. CNT Biosynthesis

Step 2. CNT storage

Step 3. CNT release into synaptic cleft

Step 4. Interaction with CNT receptors

Step 5. Termination of neurotransmitter action (uptake, metabolism)

2. CNS Neurotransmitters, Receptors and Signal Transducers

3. Structural Features of CNS CNTs

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ANESTHETIC AGENTS

1. General Anesthetics

a. Structural classes of inhalation general anesthetics

1) Hydrocarbons

2) Ethers

3) Halogenate hydrocarbons and ethers

b. Important physicochemical properties of inhalation general anesthetics

1) Volatility (administration, odor, pungency)

2) Solubility (potency/MAC), onset, duration)

3) Reactivity and therapeutic consequences

a) Peroxidation of ethers

b) Elimination of halide

c) Biotransformation

c. Mechanism of action of inhalation general anesthetics.

d. Parenteral Anesthetics

1) Mechanism of anesthetic activity (where known)

2) Formulation for I.V. administration

2. Local Anesthetics

a. Introduction - therapeutic applications

b. General structural features

c. Mechanism of action - role of relative solubility

d. Clinically relevant physicochemical properties

1) Acid-base character

2) Reactivities

a) Salt formation

b) Hydrolysis

3) Relative solubility

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