PY 420 - Med. Chem. I

Case Study #1

Read the following case then answer the six (6) questions that follow concerning this case. When you have answered the questions to your satisfaction, click on the {SUBMIT} button at the bottom of the page to Email your responses to Dr. Riley. Your answers must be submitted no later that October 7, 1996 for you to receive credit.

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You are talking with patient BRP about his purchase of Advil^® (ibuprofen) in your community pharmacy. BRP is an athletic individual who is taking the Advil^® for an inflamed knee related to his training for a local marathon run. He complains that, even though he has drastically reduced his running, he experiences mild pain in his knee between doses. Upon questioning the patient further, you find that he consumes approximately 1 gallon of a popular sports drink containing a high concentration of sodium citrate (which alkalinizes the urine) per day. BRP has a urinary pH of 7.5 and the pKa of ibuprofen is 4.5

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1. With respect to acid-base character, ibuprofen is: (Select your response from the pull-down menu.)

Acidic Basic Neutral Amphoteric

2. Select the acid-base property that best describes sodium citrate.
(Select your response from the pull-down menu.)

Salt of a strong acid and a weak base Salt of a weak acid and a strong base Salt of a strong acid and a strong base Salt of a weak acid and weak base

3. What would be the ratio of ionized to unionized forms of ibuprofen in BRP's urine?
(Select your response from the pull-down menu.)

1:1 100:1 1,000:1 1:100

4. The pH of a 1 molar solution of sodium citrate in H₂O will be: (Select your response to each of the questions below from the pull-down menu.)

1 to 3 3 to 7 Neutral >7

5. How do you explain the inadequate therapeutic response of BRP to Advil^® therapy?
(Enter your answer in the text area that follows.)

6. What advice would you offer to BRP concerning his sports drink intake? Suppose he asks, "How is the sports drink affecting the analgesic activity of Advil^®? How would you answer this question?
(Phrase your answer in the text area below in the format: I would tell BRP, " ...")

Enter your University ID number in the following text area then click on the SUBMIT button below to send by Email or click on the CLEAR button to redo your answers.

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