Medicinal Chemistry I
    PY420

    Class Location: Pharmacy Auditorium (PY101A)
    Scheduled Hours: MTHF, 9:10-10:00AM

    Course Goals and Learning Objectives
    Course Outline
    Course Exam Schedule and Grading Policy
    Course Requirements and Policies
    Course References
    Case Studies
    Course Exams
    Study Guides
    Remedial Materials
    Grade Check
    Query Form

  • Course Goals and Learning Objectives:

    • Goals: To instruct pharmacy students in the medicinal chemistry aspects of drugs affecting the central and peripheral nervous systems.

    Learning Objectives:For each therapeutic class described in Medicinal Chemistry I, the student will have knowledge of:
    (1) General structural features of agents belonging to the therapeutic class
    (2) Relevant physicochemical properties
    (3) Relevant chemical reactions
    (4) Structural and chemical influences on mechanism of pharmacologic action
    (5) Chemical influences on pharmacologic/toxicologic/therapeutic profiles
    (6) Chemical influences on biodisposition
    (7) Chemical influences on interactions
    (8) Chemical influences on dosage formulations
    (9) Miscellaneous chemical and/or structural aspects involving the therapeutic class

  • Course Outline

    • Drugs Affecting the Central Nervous System (CNS)

    1. Biochemical Aspects of Chemical Neurotransmission
    a. Chemical neurotransmitters (CNTs) in the CNS
    b. General aspects of the CNT life cycle
    2. Drugs Affecting Neuronal Structure/Function
    a. General anesthetics
    b. Local anesthetics
    3. Drugs Affecting Enkephalinergic neurotransmission
    a. Opiates and related analgesics
    b. Nonsteroidal antiinflammatory drugs (NSAIDs)
    4. Drugs Affecting Amino Acid Neurotransmission
    a. Barbiturates and related compounds
    b. Alcohol and aldehyde derivatives
    c. Benzodiazepines
    d. Anticonvulsant/Antiepileptic Agents
    e. Muscle Relaxants
    5. Drugs Affecting Biogenic Amine Neurotransmission (DA and 5-HT)
    a. Antiparkinson drugs
    b. Antipsychotic drugs
    c. Antidepressants
    d. Miscellaneous agents

    Drugs Affecting the Peripheral Nervous System (CNS)

    1. Drugs Affecting Cholinergic Neurotransmission
    a. Cholinomimetics
    b. Cholinolytics
    1) Antimuscarinics
    2) Neuromuscular blocking agents

  • Course Exam Scheduling and Grading Policy

    • DAY DATE . POINTS GRADE
    Tues. Oct. 8th . 92-100 A
    Tues. Oct. 22nd . 82-91.9 B
    Tues. Nov. 5th . 72-81.9 C
    Tues. Nov. 19th . 62-71.9 D
    Tues. Dec. 3rd . <62 F

    Five (5) non-comprehensive quizzes have been scheduled during Fall Quarter (see schedule above). Students can earn a maximum of 150 points on each quiz. These quizzes will be administered during the last 30 minutes of class time on the appointed day and date. A final exam will be given on Saturday, December 7, 1996 from 9:00 a.m. to 11:30 a.m. in Pharmacy Auditorium 101A. This examination will be comprehensive in scope and students can earn a maximum of 250 points on this exam. A student's final grade will be assigned on the basis of the point scale listed in columns 3 and 4 of the table above.

    It is course policy to NOT permit makeup of missed examinations. Consideration of allowing a makeup exam for an absence due to an extreme emergency will be made upon presentation of appropriate documentation. Makeup quizzes will only be scheduled on Friday, December 6th.

  • Course Requirements and Policies

    • Information sources for Med. Chem. I consist of (1) lecture material, (2) study guide and (3) course Web page. Lectures will supplement information found in the study guide and on the Web page. Complete understanding of course material will require regular attendance and attention at all class lectures! Quiz and exam questions will be obtained from lecture materials.

  • Course References

    • A lecture guide for PY420, Fall Quarter 1996, is available and will provide an outline of course information along with specific chemical and structural data to facilitate student's note taking. The Med. Chem. I web page will provide links to (1) remedial information as well as (2) additional information sources important to the various topics discussed in the course.

  • Case Studies

    • Case Study #1
    Case Study #1-KEY
    Case Study #2

  • Course Quizzes and Exams (Practice and Keys)

    • Quiz #1 - KEY
    Quiz #2 - KEY
    Quiz #3 - KEY
    Quiz #4 - KEY
    Quiz #5 - KEY
    Final Exam - Practice (KEY)

  • Course Study Guides

    • Study Guide One
    Study Guide Two
    Study Guide Three
    Study Guide Four
    Study Guide Five


  • Course Remedial Material

    • Chemistry Reviews OnLine
    Primer on Solubility of Organic Medicinal Agents (OMAs)
    Primer on Acid-Base Properties of OMAs
    Estimating the Solubility of an OMA
    Review of Chemical Neurotransmission


  • Grade Check

    • Click here to check on your quiz grades.

  • Query Form

    • If you have any questions, requests for information, comments, etc. enter them below, then forward to me by clicking on SEND button. If the Q&A generated here is of general interest to the class they will be posted on the Q and A Page


           



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