Dr. Yongjiang Li

Yongjiang Li was one of the Original Three graduate students to join the Goodwin Laboratory.  As with his cohorts Dr. Neil Varnado and Dr. Rue Baker, these three laid the foundation from which every subsequent graduate student has drawn.  Li came to us from Hefei, China.  Li received his undergraduate training in Chemistry from Fudan University.  As a result of his efforts there, he was honored with a People's Award each year from 1994 - 1998.  Li was active in research before coming to Auburn, and contributed to several publications (see below).  In his time here at Auburn, Li was twice recognized as a Professor Samuel H. Nichols Summer Research Fellow.  Li's research efforts in the Goodwin laboratory were focused in two areas:  1)  Methods of activation of bacterial catalase-peroxidases, and 2) the generation and characterization of deletion mutants of bacterial catalase-peroxidases.  Li successfully defended his doctoral dissertation in July 2005.  It is entitled Roles of Two Interhelical Insertions in Catalase-Peroxidase Catalysis:  Tracing the Impact of Peripheral Protein Structures on Heme Enzyme Function.  As one can observe below, Dr. Li's work had a substantial impact on our progess in the understanding of KatG catalysis after his departure.  Dr. Li engaged in postdoctoral research at the National Institutes of Health, and subsequently at the Scripps Institute in La Jolla, CA.  Dr. Li is currently a Research Associate at Scripps.

Abstracts and Publications

Kudalkar, S.N., Njuma, O.J., Li, Y., Muldowney, M., Fuanta, N.R., and Goodwin, D.C. 2015. "A role for catalase-peroxidase large loop 2 revealed by deletion mutagenesis: Control of active site water and ferric enzyme reactivity" Biochemistry 54, 1648 - 1662.

Kudalkar, S.N., Campbell, R.A., Li, Y., Varnado, C.L., Prescott, C., and Goodwin D.C.  2012.  Enhancing the peroxidatic activity of KatG by deletion mutagenesis J. Inorg. Biochem. 116, 106 - 115.

Li, Y., and Goodwin D. C.  2004.  Central participation of an interhelical insertion in catalase-peroxidase bifunctionality and resistance to peroxide-dependent inactivation.  Amer. Chem. Soc. Southeast Regional Meeting, Research Triangle Park, NC.

Li, Y., and Goodwin D. C.  2004.  Vital roles of an interhelical insertion in catalase-peroxidase bifunctionality. Biochem. Biophys. Res. Comm. 318, 970 - 976.

Li, Y., and Goodwin, D. C.  2003.  Use of deletion mutagenesis to determine the novel functions of two unique interhelical insertions in catalase-peroxidases.  Amer. Chem. Soc. Southeast Regional Meeting, Atlanta, GA.

Goodwin, D. C., Baker, R. D., Varnado, C. L., and Li, Y.  2003.  Structural requirements for the hemoprotein-dependent decomposition of hydroperoxides:  lessons from the catalase-peroxidases.   Amer. Chem. Soc. Southeast Regional Meeting, Atlanta, GA.

Li, Y., and Goodwin, D. C.  2003.  Roles of two interhelical insertions in catalase-peroxidase bifunctionality.  Amer. Chem. Soc. 226th National Meeting, New York, NY.

Goodwin, D. C., Baker, R. D., and Li, Y.  2003.  Protein structural contributions to the unique catalytic properties of catalase-peroxidases.  Amer. Chem. Soc. 226th National Meeting, New York, NY.

Goodwin, D. C., Baker, R. D., and Li, Y.  2003.  Protein structural contributions to the unique catalytic properties of catalase-peroxidases.  Enzymes, Coenzymes, and Metabolic Pathways Gordon Conference, Meriden, NH.

Baker, R., Li, Y., and Goodwin D.  2002.  Selective elimination of catalase activity from catalase-peroxidase by deletion mutagenesis.   Am. Chem. Soc. Southeast Regional Meeting, Charleston, SC.

Goodwin, D. C., Li, Y., Baker, R. D.  2002.  Selective elimination of catalase activity from catalase-peroxidases by deletion mutagenesis.  Enzymes, Coenzymes, and Metabolic Pathways Gordon Conference, Meriden, NH.

Li, Y., P. Melius, and D. C. Goodwin.  2001.  Activation of bacterial catalase-peroxidase by addition of hemin.  Am. Chem. Soc. Southeast Regional Meeting, Savannah, GA.

Wei-Jiang Wang, He-Xing Li, Song-Hai Xie, Yong-Jiang Li, Jing-Fa Deng.  1999.  Regeneration at room-temperature for amorphous NiB/SiO2 catalyst deactivated in cyclopentadiene hydrogenation. Applied Catalyst A: General 184, 33-39.

Li-Wei Guo, Xiang Gao, Dan-Wei Zhang, Shi-Hui Wu, Hou-Ming Wu, Yong-Jiang Li.  1999.  Easy access to [60]fulleroalkaloids via photoinduced reactions of tertiary amines with [60]fullerene. Chem. Lett. 5 , 411.

Xiang Gao, Sheng-Lei Ma, Li-Wei Guo, -Wei Zhang, Shi-Hui Wu, Hou-Ming  Wu, Yong-Jiang Li.  1999.  Unusual products of enamines with [60]fullerene. Chem. Lett. 7, 671.

Ma, Sheng-Lei; Li, Wen-Yu; Zhang, Dan-Wei; Wu, Shi-Hui; Gao, Xiang; Wu, Hou-Ming; Li, Yong-Jiang; Wang, Zhong-Hua.  2001.  Reactions of [60]fullerene with azo ylides from heteroaromatics.    Huaxue Xuebao 59,  1344.

Guo, Li-Wei; Gao, Xiang; Zhang, Dan-Wei; Wu, Shi-Hui; Wu, Hou-Ming; Li, Yong-Jiang; Wilson, Stephen R.; Richardson, Christine F.; Schuster, David I.  2000.  Alkaloid-Fullerene Systems through Photocycloaddition Reactions.  Journal of Organic Chemistry 65,  3804.