Kim joined the Goodwin Laboratory during her junior year
of high school. She spent her first summer in the laboratory
learning the ropes. To borrow a cliche, Kim took to the lab
like a duck to water, identifying her own nickname, the "Mad
Scientist". During her second summer, Kim contributed a
great deal to our project on peroxidase-catalyzed oxidation of
naturally occuring o-methoxyphenols. She spent many
hours carrying out sequential-mixing stopped-flow experiments.
By the end of the summer, she had collected rate constants
(in triplicate) for fourteen different reactions. In the
following year she came to Auburn University as an undergraduate,
and she continued her work with us. Her efforts contributed a
substantial part of one of our presentations at the American
Chemical Society National Meeting in New York (September 7 - 11,
2003). She is a co-author on an invited book chapter arising
from that presentation, and she presented an award-winning poster
at the Southeast Regional Meeting of the American Chemical Society
in Atlanta, GA (November 16 - 19, 2003). She shared First-Place
among posters presented by undergraduate students. Kim was
honored as an Auburn University Undergraduate Research Fellow.
Finally, Kim applied site-directed mutagenesis to evaluate
the role of a set of highly conserved residues in
and catalysis. In keeping with her high level of
gave an oral presentation of her results the 2004
Meeting of the American Chemical Society at Research Triangle
For her talk she was given an award (Second-Place award in
Division for undergraduate talks).
Abstracts and Publications
Moore, R., Goodwin, D. C., Laband, K. A., and Powell, L.
of interdomain salt bridge on catalase-peroxidase activity.
Chemical Society, 231st National Meeting, Atlanta, Georgia.
Goodwin, D. C., Laband, K. A., and Hertwig, K. M. 2005.
Oxidation of capsaicinoids by peroxidases: kinetic,
structural, and physiological considerations. In
Phenolics in Foods and Natural Health Products.
Shahidi, F., and Ho, C. T., Eds. ACS Symposium Series,
Vol. 909, pp. 161 - 174.
Laband, K. A., Baker, R. D., and Goodwin, D. C. 2004.
Contributions of an interdomain ion pair to the bifunctional
properties of catalase-peroxidases. Amer. Chem. Soc.
Southeast Regional Meeting, Research Triangle Park, NC.
Goodwin, D. C., Baker, R. D., Cook, C. O., and Laband, K. A. 2004.
Integral Involvement of an “Inactive” Domain in
Catalase-Peroxidase Structure and Catalysis. Enzymes,
Coenzymes, and Metabolic Pathways Gordon Conference,
Laband, K. A., and Goodwin, D. C. 2003.
Peroxidase-catalyzed oxidation of plant-derived o-methoxyphenols:
implications for the
metabolism of health-promoting phenolic compounds. Amer.
Soc. Southeast Regional Meeting, Atlanta, GA.