Carma started with us as a Masters student, and then switched to the
PhD program. She hails from Sylacauga, AL, and completed her
Bachelor or Science degree in Chemical Engineering here at Auburn
University. During her time in the Goodwin lab, Carma received
of two prestigious fellowships. First, she was an Alabama
LSAMP-NSF Bridge to the Doctorate Fellow, and she has twice been
selected as an NSF GK-12 fellow. Carma also received a
Dean's Research Award, and she is a member of the Alpha Theta Chi
Honor Society. On December 4, 2008, Carma successfully
defended her dissertation entitled: Role of distant, intrasubunit residues in
catalase-peroxidase catalysis: Tracing the role of gene
duplication and fusion in enzyme structure and function.
Carma is now a Chemistry faculty member at Chattanooga State
Community College.
Abstracts and Publications
Cook, C.O., Moore, R.L., and Goodwin, D.C. 2008. The
effect of R117 and D597 interdomain residue substitutions on the
reactivation of Escherichia coli
catalase-peroxidase. NOBCChE
Proceedings 35.
Cook, C.O., Moore, R.L., and Goodwin, D. C. 2008. Role of R117
and D597 interdomain residues in the reactivation of E. coli
catalase-peroxidase. American Chemical Society, 235th National
Meeting, New Orleans, LA.
Moore, R.L., Cook, C.O., Williams, R., and Goodwin, D.C.
2008. Substitution of strictly conserved Y111 in
catalase-peroxidase: Impact of remote interdomain contacts on
active site structure and catalytic performance. J. Inorg. Biochem. 102, 1819 -
1824.
Cook, C.O., and Goodwin, D.C. 2008. Role of the central
hydrogen bonding network interdomain residues in the bifunctionality
of catalase-peroxidases. NOBCChE 35th Annual Conference,
Philadelphia, PA.
Cook, C.O., Moore, R.L., Goodwin, D.C. 2007. Effect of Distant,
Intradomain Residues on Restoring the Catalase-Peroxidase
Bifunctional Active Site, Southeast Regional Meeting of the American
Chemical Society, Greenville, SC.
Goodwin, D.C., Cook, C.O., Moore, R.L. 2007. Roles of distant
but highly conserved interactions in maintaining active site
function in catalase-peroxidases. Gordon Conference: Enzymes,
Coenzymes, and Metabolic Pathways, Biddeford, ME.
Cook, C. O., Moore, R. L., Goodwin, D. C. 2007. Role of intrasubunit
interactions between domains in catalase-peroxidase structure and
activity. American Chemical Society, 233rd National Meeting, Boston,
MA.
Baker, R. D., Cook, C. O., and Goodwin D. C. 2006.
Catalase-peroxidase active site restructuring by a distant and
'inactive' domain. Biochemistry 45, 7113-7121.
Goodwin, D. C., Cook, C. O., Baker, R. D. 2006.
Modulation of catalase-peroxidase active site structure and
catalysis by distant protein structures. American Chemical
Society, 231st National Meeting, Atlanta, Georgia.
Cook, C. O., Baker, R., and Goodwin, D. C. 2006.
Function of a gene-duplicated domain in catalase-peroxidase
structure and activity. American Chemical Society, 231st
National Meeting, Atlanta, Georgia.
Cook, C. O., Baker, R. D., and Goodwin, D. C., 2004
Catalase-peroxidase active site restructuring by a distant and
"inactive" domain. Amer. Chem. Soc. Southeast Regional
Meeting, Research Triangle Park, NC.
Baker, R. D., Cook, C. O., and Goodwin D. C., 2004 Essential
contribution of the C-terminal domain to the structure of the
catalase-peroxidase active site. Amer. Chem. Soc. Southeast
Regional Meeting, Research Triangle Park, NC.
Goodwin, D. C., Baker, R. D., Cook, C. O., and Laband, K. A. 2004.
Integral Involvement of an “Inactive” Domain in
Catalase-Peroxidase Structure and Catalysis. Enzymes,
Coenzymes, and Metabolic Pathways Gordon Conference, Meriden,
NH.
Baker, R. D., Cook, C. O., and Goodwin D. C. 2004. Properties
of catalase-peroxidase lacking its C-terminal domain. Biochem.
Biophys.
Res. Comm. 320, 833-839.