Jessica Krewall

Jessica came to Auburn University in August 2015, and she joined the Goodwin Laboratory in January 2016.  Originally, from Colorado Springs, she comes to us by way of Wayland Baptist University in Plainview, TX. So, not only do she and Doc hail from the same town, but Jessica carried out her research under the supervision of Dr. Robert Moore.  Yes, that Robert Moore.  After completing his PhD here at Auburn, Dr. Moore joined the faculty at Wayland. Jessica was a star student in the classroom and in the lab, so we are very glad to have her here. In the Goodwin Lab, Jessica is evaluating mechanisms of KatG catalysis. Her studies are expected to include the pathways of intramolecular electron transfer in the KatG protein and their relation to synthesis of the novel Met-Tyr-Trp covalent adduct cofactor and enzyme activity.

Publications and Abstracts

Njuma, O. J., Davis, I., Ndontsa, E. N., Krewall, J. R., Liu, A., and Goodwin, D. C. 2017. Mutual synergy between catalase and peroxidase activities of the bifunctional enzyme KatG is facilitated by electron-hole hopping within the enzyme. J. Biol. Chem. 292, 18408 - 18421.

Krewall, J. R., Njuma, O. J., and Goodwin, D. C. 2017. Role reversal between peroxidase reaction intermediates generates the distinct catalase mechanism of catalase-peroxidase. 46th Annual Southeast Magnetic Resonance Conference, Tallahassee, FL, (10/29/17).

Xu, H., Krewall, J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves the catalase activity of KatG: Strategic use of an active-site tryptophan for off-pathway electron transfer. 46th Annual Southeast Magnetic Resonance Conference, Tallahassee, FL, (10/29/17).

Xu, H., Krewall, J. R., Njuma, O. J., Davis, I., Liu, A., and Goodwin, D. C. 2017. Using an arginine switch and an active site tryptophan to direct off-pathway electron transfer: Maximizing catalase activity from a peroxidase scaffold. Gordon Research Conference: Enzymes, Coenzymes, and Metabolic Pathways, Waterville Valley, NH, (7/16/17 – 7/21/17).

Krewall, J. R., Xu, H., Njuma, O. J., and Goodwin, D. C. 2017. Directing off-pathway protein oxidation to preserve enzyme activity: At last, a role for the proximal tryptophan of KatG. 8th Annual Southeast Enzyme Conference, Atlanta, GA, (04/08/17).

Xu, H., Krewall, J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves the catalase activity of KatG: Strategic use of an active-site tryptophan for off-pathway electron transfer. 8th Annual Southeast Enzyme Conference, Atlanta, GA, (04/08/17).