Hui Xu

Hui Xu joined the Department of Chemistry and Biochemistry in the Fall of 2013, and she joined the Goodwin laboratory in May of 2014. Hui Xu's undergraduate degree is in Health Sciences, so this represents a considerable shift in emphasis for her. In addition to taking courses above and beyond those taken by our typical graduate students, Hui has been evaluating the connection between the unique arginine switch of KatG enzymes and off-catalase radical transfer. So far, her studies have taken her into site-directed mutagenesis, steady-state kinetic evaluation, stopped-flow rapid reaction analyses, and most recently, rapid freeze-quench EPR.

Publications and Abstracts

Xu, H., Krewall, J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves the catalase activity of KatG: Strategic use of an active-site tryptophan for off-pathway electron transfer. 46th Annual Southeast Magnetic Resonance Conference, Tallahassee, FL, (10/29/17).

Xu, H., Krewall, J. R., Njuma, O. J., Davis, I., Liu, A., and Goodwin, D. C. 2017. Using an arginine switch and an active site tryptophan to direct off-pathway electron transfer: Maximizing catalase activity from a peroxidase scaffold. Gordon Research Conference: Enzymes, Coenzymes, and Metabolic Pathways, Waterville Valley, NH, (7/16/17 – 7/21/17).

Krewall, J. R., Xu, H., Njuma, O. J., and Goodwin, D. C. 2017. Directing off-pathway protein oxidation to preserve enzyme activity: At last, a role for the proximal tryptophan of KatG. 8th Annual Southeast Enzyme Conference, Atlanta, GA, (04/08/17).

Xu, H., Krewall, J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves the catalase activity of KatG: Strategic use of an active-site tryptophan for off-pathway electron transfer. 8th Annual Southeast Enzyme Conference, Atlanta, GA, (04/08/17).