Department of Chemistry and
Biochemistry
Auburn University
Auburn, AL 36830
Ph.D., Biochemistry, Department of Chemistry and Biochemistry, Utah
State University, August 1996, Thesis:
Redox Mediation in
Peroxidase-Catalyzed Oxidation
B.A., Food, Nutrition, and Dietetics; Minor: Chemistry; University of
Northern Colorado, December 1991, Magna Cum Laude
Associate Professor, Department of Chemistry and Biochemistry,
Auburn University, Auburn, AL, August 2005 – present
Assistant Professor, Department of Chemistry, Auburn University,
Auburn, AL, September 1999 – July 2005
DeanÕs Award for Outstanding Advisor. College of Sciences and
Mathematics, Auburn University, April 2017.
Auburn University Student Government Association Outstanding
Faculty Member Award. Auburn University,
April 2015.
College of Sciences and Mathematics Faculty Service/Outreach Award. Auburn University,
April 2015.
American Chemical Society Outreach Volunteers of the Year. Auburn Section of
the American Chemical Society, February 2014.
College of Sciences and Mathematics Outstanding Teacher Award. Auburn University,
April 2011.
Alpha Epsilon Delta Honorary National Membership. Awarded by the Auburn University AED
Chapter, April 2011.
Golden Key National Honor Society Teaching Award. Golden Key Honor Society, Auburn
University Chapter, April 2001.
Center in Molecular Toxicology Postdoctoral Research Trainee. Department of Biochemistry, Vanderbilt
University School of Medicine, July 1998 – August 1999.
Thomas
F. Emery Memorial Research Scholar. Department of Chemistry and
Biochemistry, Utah State University, May 1995.
Willard L. Eccles Family Foundation Fellow. College of Science, Utah State
University, October 1992- September 1995.
George H. and Billie Bush Emert Scholar. Department of Chemistry and
Biochemistry, Utah State University, May 1996.
E.L. and Inez Waldron Travel Award. Biotechnology Ctr, Utah State
University, June 1996.
40.
Simithy, J., Fuanta,
N. R., Alturki, M., Hobrath, J. V., Wahba, A. E., Rath, J., Hamann, M. T.,
DeRuiter, J., Goodwin, D. C., and Calder—n, A. I. 2018. Slow-binding inhibition
of Mycobacterium tuberculosis
shikimate kinase by manzamine alkaloids. Biochemistry
(submitted).
39.
Simithy, J., Fuanta, N. R., Kochanowska-Karamayan, A., Hamann, M. T.,
Goodwin, D. C., and Calder—n, A. I. 2018. Mechanism of irreversible inhibition
of Mycobacterium tuberculosis
shikimate kinase by ilimaquinone. Biochim.
Biophys. Acta 1866, 731 – 739.
38.
Alturki, M. S., Fuanta, N. R., Jarrard, M. A., Hobrath, J. V., Goodwin,
D. C., Rants-o, T. A., and Calder—n, A. I. 2018. Detection of non-specific
inhibitors of Mycobacterium tuberculosis
shikimate kinase. Bioorg. Medicin. Chem.
Lett. 28, 802 – 808.
37.
Njuma, O. J., Davis, I., Ndontsa, E. N., Krewall, J. R., Liu, A., and
Goodwin, D. C. 2017. Mutual synergy between catalase and peroxidase activities
of the bifunctional enzyme KatG is facilitated by electron-hole hopping within
the enzyme. J. Biol. Chem. 292, 18408
– 18421.
36. McCarty, S. E., Schellenberger, A., Goodwin, D. C., Fuanta,
N. R., Tekwani, B. L., and Calder—n, A. I. 2015. Plasmodium falciparum thioredoxin reductase (PfTrxR) and its role
as a target for antimalarial discovery. Molecules
20, 11459 – 73.
35.
Huang, J., Smith, F., Panizzi, J.R., Goodwin, D. C., and Panizzi, P.
2015. Inactivation of myeloperoxidase by benzoic acid hydrazide. Arch. Biochem. Biophys. 570, 14 –
22.
34.
Kudalkar, S., Li, Y., Muldowney, M., and Goodwin, D.C. 2015. A role for
catalase-peroxidase large loop 2 revealed by deletion mutagenesis: Control of
active site water and ferric enzyme reactivity. Biochemistry 54, 1648 - 1662.
33.
Gordon, S., Simithy, J., Goodwin, D. C., and Calder—n, A. I. 2015.
Selective Mycobacterium tuberculosis shikimate
kinase inhibitors as potential antibacterials. Perspec.
Med. Chem. 7, 9 – 20.
32.
Simithy, J., Gill, G., Wang, Y., Goodwin, D. C., and Calder—n, A. I.
2015. Development of an ESI-LC-MS-based assay for kinetic evaluation of M. tuberculosis shikimate kinase
activity and inhibition. Anal. Chem. 87,
2129 – 2136.
31. Njuma, O. J., Ndontsa, E. N., and
Goodwin D. C. 2014. Catalase in peroxidase clothing: Interdependent cooperation
of two cofactors in the catalytic versatility of KatG. Arch. Biochem. Biophys. 544, 27 – 39.
30. Wang, Y., and Goodwin, D. C. 2013. Integral role of the I*-helix in the
function of the inactive C-terminal domain of catalase-peroxidase (KatG). Biochim.
Biophys. Acta 1834, 362 – 371.
29. Kudalkar, S. N., Campbell, R. A., Li,
Y., Varnado, C. L., Prescott, C., and Goodwin, D. C. 2012. Enhancing peroxidatic turnover of KatG
by deletion mutagenesis. J. Inorg. Biochem. 116, 106 – 115.
28. Ndontsa, E. N., Moore, R. L., and Goodwin, D. C. 2012. Stimulation of KatG catalase activity by
peroxidatic electron donors. Arch. Biochem. Biophys. 525, 215 –
222.
27. Tejero, J., Biswas, A., Haque, M. M., Wang, Z. Q., Hemann,
C., Varnado, C. L., Hille, R., Goodwin, D. C., and Stuehr, D. J. 2011. Mesohaem substitution reveals how haem
electronic properties can influence the kinetic and catalytic parameters of
neuronal NO synthase. Biochem. J. 433, 163 – 174.
26. Moore, R.L., Cook, C.O.,
Williams, R., and Goodwin, D. C.
2008. Substitution of strictly conserved Y111 in
catalase-peroxidase: Impact of
remote interdomain contacts on active site structure and catalytic
performance. J. Inorg. Biochem. 102, 1819 – 1824.
25. Cook, C.O., Moore,
R.L., and Goodwin, D.C. 2008. The effect of R117 and D597 interdomain
residue substitutions on the reactivation of Escherichia coli catalase-peroxidase. NOBCChE
Proceedings 35.
24. Moore, R.L., Powell, L.J., and
Goodwin, D. C. 2008. The kinetic
properties producing the perfunctory pH profiles of catalase-peroxidases. Biochim. Biophys. Acta. 1784, 900
– 907.
23. Trostchansky, A., O-Donnell,
V.B., Goodwin, D.C., Landino, L.M., Marnett, L.J., Radi, R., and Rubbo, H. 2007. PGHS-1 in turnover is inactivated by
peroxynitrite derived- radicals: Differential effect of .NO on peroxidase and cyclooxygenase activities. Free Rad. Biol. Med. 41, 1029 –
1038.
22.
Baker, R. D., Cook, C. O., and Goodwin, D. C. 2006. Catalase-peroxidase active site
restructuring by a distant an inactive domain. Biochemistry
45, 7113-7121.
21. Goodwin, D. C., Laband, K. A., and Hertwig, K.
M. 2005. Capsaicinoid oxidation by peroxidases: kinetic, structural, and physiological
considerations. In Phenolics in
Foods and Natural Health Products.
Ho, C. T., and Shahidi, F., Eds. ACS
Symposium Series, Vol. 909, pp. 161-174.
20.
Baker, R. D., Cook, C. O., and Goodwin, D. C. 2004. Properties of catalase-peroxidase lacking
its C-terminal domain. Biochem. Biophys. Res. Comm. 320,
833-839.
19. Li,
Y., and Goodwin, D. C. 2004. Vital
roles of an interhelical insertion in catalase-peroxidase bifunctionality. Biochem. Biophys. Res. Comm. 318, 970-976.
18. Varnado, C. L., and
Goodwin, D. C. 2004. System for the expression of recombinant
hemoproteins in Escherichia coli. Prot. Exp. Purif. 35, 76-83.
17. Varnado, C. L., Hertwig, K. M., Thomas, R., Roberts, J. K.,
and Goodwin, D. C. 2004. Properties
of a novel periplasmic catalase-peroxidase from Escherichia coli O157:H7.
Arch. Biochem. Biophys. 421,
166-174.
16. Goodwin, D.C., and Hertwig, K. M. 2003. Peroxidase-catalyzed oxidation of
capsaicinoids: Steady-state and
transient-state kinetic studies. Arch. Biochem. Biophys. 417, 18-26.
15. Goodwin, D.C., Rowlinson, S. W., and
Marnett, L. J. 2000. Substitution of tyrosine for the
proximal histidine ligand to the heme of prostaglandin endoperoxide
synthase-2: Implications for the
mechanism of cyclooxygenase activation and catalysis. Biochemistry
39, 5422-5432.
14. Kiefer, J. R., Pawlitz, J. L., Moreland,
K. T., Stegeman, R. A., Hood, W. F., Gierse, J. K., Stevens, A. M., Goodwin, D. C,
Rowlinson, S. W., Marnett, L. J., Stallings, W. C., and Kurumbail, R. G. 2000. Structural insights into the
stereochemistry of the cyclooxygenase reaction. Nature
405, 97-101.
13. Rowlinson, S. W., Crews, B. C., Gierse,
J. K., Goodwin, D. C. and Marnett, L. J. 2000. Spatial requirements for 15-HETE
synthesis within the cyclooxygenase active site of murine COX-2: why acetylated COX-1 does not synthesize
15-R-HETE. J. Biol. Chem. 275,
6586-6591.
12. Goodwin, D. C., Landino, L. M., and
Marnett, L. J. 1999. Effects of nitric oxide and nitric
oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin
biosynthesis. FASEB J. 13, 1121-1136.
11. Goodwin, D. C., Landino, L. M., and
Marnett, L. J. 1999. Reactions of prostaglandin endoperoxide
synthase with nitric oxide and peroxynitrite. Drug Metabolism Reviews 31,
273-294.
10. Marnett, L. J., Rowlinson, S. W.,
Goodwin, D. C., Kalgutkar, A. S., and Lanzo, C. A. 1999. Arachidonic acid oxygenation by COX-1
and COX-2: Mechanisms of catalysis and inhibition. J.
Biol. Chem. 274, 22903-22906.
9. Marnett, L. J., Goodwin, D. C., Rowlinson,
S. W., Kalgutkar, A. S., and Landino, L. M. 1999. Structure, function, and inhibition of
prostaglandin endoperoxide synthase. In Comprehensive
Natural Products Chemistry, Vol. V pp. 225-261. C.D. Poulter, Ed. Elsevier
Science, Amsterdam.
8. Goodwin, D. C., Gunther, M. R., Hsi, L.
C., Crews, B. C., Eling, T. E., Mason, R. P., and Marnett, L. J. 1998. Nitric oxide trapping of tyrosyl
radicals generated during prostaglandin endoperoxide synthase turnover:
detection of the radical derivative of tyrosine 385. J. Biol. Chem. 273,
8903-8909.
7. Goodwin, D. C., Grover, T. A., and Aust,
S. D. 1997. Roles of efficient substrates in
peroxidase-catalyzed oxidations. Biochemistry
36, 139-147.
6. Goodwin, D. C., Grover, T. A., and Aust,
S. D. 1996. Redox mediation in the
peroxidase-catalyzed oxidation of aminopyrine: possible implications for
drug-drug interactions. Chem. Res.
Toxicol. 9, 476-483.
5. Goodwin, D. C., Aust, S. D., and Grover,
T. A. 1996. Free radicals produced during oxidation
of hydrazines by hypochlorous acid.
Chem. Res. Toxicol. 9, 1333-1339.
4. Goodwin, D. C., Aust, S. D., and Grover,
T. A. 1995. Evidence for veratryl alcohol as a redox
mediator in lignin peroxidase-catalyzed oxidation. Biochemistry
34, 5060-5065.
3. Goodwin, D. C., Yamazaki, I., Aust, S.
D., and Grover, T. A. 1995. Determination of transient-state rate
constants for rapid peroxidase reactions. Analyt.
Biochem. 231, 333-338.
2. Goodwin, D.C., Barr, D. P., Aust, S. D.,
and Grover, T. A. 1994. The role of oxalate in lignin peroxidase
catalyzed reduction: Protection from compound III accumulation. Arch.
Biochem. Biophys. 315: 267-272.
1. Goodwin, D.C., and Lee, S. B. 1993. Rapid, microwave mini-prep of total
genomic DNA from fungi, plants, protists and animals for PCR. Biotechniques
15: 438- 444.
E. Patents and Inventions
Hong,
J. W., Goodwin, D., Duin, E. C., Jambovane, S., Moore, R., Nam, T.-J., and Kim,
S.-K. Systems for and methods of characterizing reactions. U.S. Patent Application # 2010/0311,611.
Varnado,
C., Olson, J. S., and Goodwin, D.
C. Increasing recombinant Hemoglobin expression for blood substitute production
in E. coli by Co-Expression with the
heme receptor gene (chuA) from E. coli 0157:H7. Invention Disclosure Filed with Rice
University.
Krewall,
J. R., Njuma, O. J., Sahrmann, P., and Goodwin, D. C. 2018. How intraprotein
radical transfer and the role-reversal of heme intermediates generate a unique
catalase mechanism. 9th Annual
Southeast Enzyme Conference, Atlanta, GA, (04/07/18).
Xu,
H., Njuma, O., and Goodwin, D. C. 2018. How an arginine switch promotes the
self-preservation of an H2O2-degrading enzyme. 9th Annual Southeast Enzyme
Conference, Atlanta, GA, (04/07/18).
McWhorter,
K. L., Xu, H., and Goodwin, D. C. 2018. Exploiting active-site tryptophans to
direct off-mechanism electron transfer: Preserving the activity of
peroxide-detoxifying enzymes. 9th
Annual Southeast Enzyme Conference, Atlanta, GA, (04/07/18).
Sahrmann,
P., McWhorter, K. L., Krewall, J. R., and Goodwin, D. C. 2018. Electron-hole
hopping as catalytic self-preservation: How catalase-peroxidase from M.
tuberculosis avoids the perils of peroxide decomposition. 9th Annual Southeast Enzyme Conference Atlanta, GA,
(04/07/18).
Goodwin, D.
C., 2017. Intramolecular radical transfer: How KatG enlists self-preservation
for synergistic bifunctional catalysis. Session:
Bioinorganic Chemistry in the Southeast: From Small Molecules to
Macromolecules. SERMACS 2017, Charlotte, NC, (11/08/17).
Fuanta,
R., Simithy, J., Skinner, M., Gill, G.,
Childers, T., Calderon, A. I., and Goodwin D. 2017. An
approach towards rapid inhibitor screening and mechanistic evaluation of
tuberculosis shikimate kinase: intrinsic and extrinsic fluorescence. National Meeting of the National Organization for the Professional
Advancement of Black Chemist and Chemical Engineers (NOBCChE), Minneapolis,
MN, Oct 2017.
Krewall,
J. R., Njuma, O. J., and Goodwin, D. C. 2017. Role reversal between peroxidase
reaction intermediates generates the distinct catalase mechanism of
catalase-peroxidase. 46th
Annual Southeast Magnetic Resonance Conference, Tallahassee, FL, (10/29/17).
Xu, H., Krewall,
J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves
the catalase activity of KatG: Strategic use of an active-site tryptophan for
off-pathway electron transfer. 46th
Annual Southeast Magnetic Resonance Conference, Tallahassee, FL,
(10/29/17).
Fuanta,
R., Simithy, J., Skinner, M., Gill, G.,
Childers, T., Calderon, A. I., and Goodwin D. 2017. Imparting
intrinsic flourescence as an approach towards rapid inhibitor screening and
mechanistic evaluation of tuberculosis shikimate kinase. 254th National Meeting of the American Chemical Society, Washington
D.C, (8/17).
Xu, H.,
Krewall, J. R., Njuma, O. J., Davis, I., Liu, A., and Goodwin, D. C. 2017.
Using an arginine switch and an active site tryptophan to direct off-pathway
electron transfer: Maximizing catalase activity from a peroxidase scaffold. Gordon Research Conference: Enzymes,
Coenzymes, and Metabolic Pathways, Waterville Valley, NH, (7/16/17 –
7/21/17).
Krewall, J. R., Xu,
H., Njuma, O. J., and Goodwin, D. C. 2017. Directing off-pathway protein
oxidation to preserve enzyme activity: At last, a role for the proximal
tryptophan of KatG. 7th Annual
Lester Andrews Symposium, Starkville, MS, (05/31/17).
Xu, H., Krewall,
J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves
the catalase activity of KatG: Strategic use of an active-site tryptophan for
off-pathway electron transfer. 7th
Annual Lester Andrews Symposium, Starkville, MS, (05/31/17).
Krewall, J. R.,
Xu, H., Njuma, O. J., and Goodwin, D. C. 2017. Directing off-pathway protein
oxidation to preserve enzyme activity: At last, a role for the proximal
tryptophan of KatG. 8th Annual
Southeast Enzyme Conference, Atlanta, GA, (04/08/17).
Xu, H., Krewall,
J. R., Njuma, O. J., and Goodwin, D. C. 2017. How an arginine switch preserves
the catalase activity of KatG: Strategic use of an active-site tryptophan for
off-pathway electron transfer. 8th
Annual Southeast Enzyme Conference, Atlanta, GA, (04/08/17).
Fuanta, R.,
Simithy, J., Gill, G., Kollhoff, A., Childers, T., Calderon, A. I., and Goodwin
D. 2016. Towards high-throughput drug screening and mechanistic evaluation of
tuberculosis shikimate kinase; Intrinsic protein fluorescence. National Organization for the Professional
Advancement of Black Chemist and Chemical Engineers (NOBCChE),
Raleigh, NC (11/16).
Njuma, O. J.,
Davis, I., Ndontsa, E. N., Liu, A., and Goodwin, D.C. 2016. Pathways and
regulation of intramolecular electron transfer in catalase-peroxidases (KatG).
BEST Symposium, DOW Chemical Company (10/1/16).
Fuanta, R., Simithy, J., Gill, G.,
Kollhoff, A., Childers, T., Calderon, A. I., and Goodwin D. 2016. Targeted
intrinsic protein fluorescence, an approach towards high-throughput drug
screening and mechanistic evaluation of tuberculosis shikimate kinase. Southeast Meeting of American Chemical
Society (SERMACS), Columbia, SC (10/16).
Alturki, M.
S., Jarrad, M. A., Fuanta, N. R., Goodwin, D. C., and Calder—n, A. I. 2016.
LC-MS based approach to characterize non-specific binding inhibitors to Mycobacterium tuberculosis shikimate
kinase (MtSK). 64th
American Society for Mass Spectrometry National Conference on Mass Spectrometry
and Allied Topics, San Antonio, TX. (6/5/16).
Calder—n, A.
I., Simithy, J., Goodwin, D. C., and Hamann, M. T. 2016. Mass spectrometry
based studies on irreversible inhibition of recombinant Mycobacterium
tuberculosis shikimate kinase by the marine sponge metabolite ilimaquinone. 64th
American Society for Mass Spectrometry National Conference on Mass Spectrometry
and Allied Topics, San Antonio, TX. (6/5/16).
Department of Chemistry,
LaGrange College, March 21, 2016. Radicals and Switches: Synergy or Antagonism
in the Operation of a Bifunctional Enzyme?
Department of Chemistry and
Biochemistry, University of North Georgia, February 5, 2016. Tryptophanyl Radicals
and Arginine Switches: Synergy or Antagonism in the Operation of a Bifunctional
Enzyme?
Department of Chemistry,
Kansas State University, January 28, 2016. Tryptophanyl Radicals and Arginine Switches:
Synergy or Antagonism in the Operation of a Bifunctional Enzyme?
Njuma, O. J.,
Davis, I., Ndontsa, E. N.,
Liu, A., and Goodwin, D.C. 2015. The proximal tryptophan as a potential conduit
for catalase-peroxidase inactivation. 42nd National Organization for the Professional Advancement of Black Chemists
and Chemical Engineers
(NOBCCHE), Orlando, FL. (9/21/15).
Njuma, O. J., Davis, I., Ndontsa, E.
N., Liu, A., and Goodwin, D. C. 2015. Proximal tryptophan and arginine switch
participation in catalase-peroxidase inactivation. Gordon Research Conference: Enzymes, Coenzymes, and Metabolic Pathways,
Waterville Valley, NH (7/13/15 -7/14/15).
Njuma, O. J., Davis, I., Ndontsa, E.
N., Liu, A., and Goodwin, D. C. 2015. Participation of the proximal tryptophan
as a potential conduit for catalase-peroxidase inactivation. 6th Annual Southeast Enzymes
Conference, Georgia State University, Atlanta, GA (4/11/15).
Fuanta, R., Simithy, J., Gill, G.,
Kollhoff, A., Childers, T., Calderon, A. I., and Goodwin D. 2015. Site-directed
incorporation of intrinsic fluorescence in shikimate kinase to evaluate
catalysis and inhibition. 6th
Annual Southeast Enzymes Conference, Georgia State University, Atlanta, GA
(4/11/15).
Auburn University
College of Sciences and Mathematics Leadership Council Meeting COSAM, October
2, 2015. COSAM Outreach in Prison
Department of Chemistry, University of Buea, Cameroon. *Njuma,
O. J., Davis, I., Ndontsa,
E. N.,
Liu, A., and Goodwin, D.C. April 1, 2015. Electron donors to the rescue: The
proximal tryptophan as a
potential conduit for catalase-peroxidase inactivation.
Njuma, O. J.,
Ndontsa, E. D., and Goodwin, D. C. 2014. Evaluating the role of peroxidatic
reducing substrates in an unusual catalase activity of catalase-peroxidases. 2014 Symposium, The Protein Society, San
Diego, CA. (7/27/14)
Simithy, J.,
Goodwin, D., Hamann, M.T., and Calderon, A.I. 2014. Evaluation of the
inhibitory activity of marine natural compounds against Mycobacterium tuberculosis shikimate kinase (MtSK) by LC-MS. 62nd
American Society for Mass Spectrometry Conference on Mass Spectrometry and
Allied Topics, Baltimore, MD (6/18/14)
Njuma, O. J.,
Ndontsa, E. D., and Goodwin, D. C. 2014. Synergistic effect of peroxidatic
electron donors on the catalase activity of Catalase-Peroxidase. 5th Annual Southeast Enzymes
Conference, Georgia State University, Atlanta, GA (4/4/14)
Fifth Annual Southeast
Enzymes Conference, Georgia State University, April 5, 2014. Session Chair,
Session 1.
Njuma, O. J.,
Ndontsa, E. N.
and Goodwin, D. C. 2014. Evaluating
the role of electron donors in a novel mechanism of H2O2
decomposition by Catalase-Peroxidase. 91st Alabama Academy of Science Meeting (AAS), Auburn University, AL (3/13/14)
McCurdy,
E., Ndontsa, E. N., and Goodwin, D. C. 2014. W438 and the diminished necessity
for peroxidatic rescue of KatG catalatic turnover. 34th Annual Undergraduate
Research Conference, University of Memphis, Memphis, TN (2/22/14)
McCurdy, E., Ndontsa, E. N.,
and Goodwin, D. C. 2013. An Investigation of
W438 as a Potential Route for Off-Pathway Electron Transfer and Its
Relationship to the Bifunctional Activity of Catalase-Peroxidase. Southeast
Regional Meeting of the American Chemical Society (SERMACS), Atlanta, GA.
(11/14/13) (Won first prize for undergraduate poster session).
Njuma, O. J., Ndontsa,
E. N.,
and Goodwin,
D. C.
2013. Rescue of catalase-inactive intermediates of KatG by peroxidatic electron
donors. Southeast Regional Meeting of the American Chemical Society
(SERMACS), Atlanta, GA (11/13/13)
Njuma, O. J., Ndontsa,
E. N
and Goodwin, D.C. 2013. KatG: Improvisation of novel peroxide
decomposition mechanisms. 99th Annual Southeastern Branch of
American Society of Microbiology Meeting (SEBASM), Auburn
University, AL (11/8/13)
Njuma,
O. J., Ndontsa, E. N., and Goodwin, D. C. 2013. Electron donors to the
rescue: Evaluating a novel mechanism of hydrogen peroxide decomposition by
catalase-peroxidases. National Meeting of the National Organization for the Professional Advancement of Black Chemists and
Chemical Engineers (NOBCCHE), Indianapolis, IN
(10/3/13)
Njuma, O. J., Ndontsa,
E. N.,
and Goodwin,
D. C.
2013. Surprising role of peroxidatic electron donors in the catalase activity
of catalase-peroxidase. Diversity
Awareness Symposium, Tuscaloosa, AL. (Award-winning
poster)
Ndontsa, E. N., and
Goodwin D. C. 2012. Multiple mechanisms for KatG catalase activity: Electron
donors, pH, and an arginine "switch.Ó 2012 Annual Meeting of the Southeast
Region of the American Chemical Society, Raleigh, NC.
Ndontsa, E. N., and Goodwin,
D. C. 2012. Role of Arg 418 switch in electron-donor-enhanced catalase activity
of M. tuberculosis catalase-peroxidase (KatG). Annual National Meeting NOBCChE,
Washington, D.C.
Department of Chemistry and
Biochemistry, Kennesaw State University, October 3, 2012. Novel
Mechanisms for Hydrogen Peroxide Degradation Catalyzed by KatG:
Implications for Antibiotic Resistance and Bacterial Virulence.
Ndontsa, E. N., and Goodwin, D. C. 2012.
Role of Arg 418 switch in electron-donor-enhanced catalase activity of M.
tuberculosis catalase-peroxidase (KatG).
Third Southeast Enzymes Conference,
Atlanta, GA.
Wang, Y., and Goodwin, D. C. 2012. The
participation of conserved IÕ-helix in structure, stability, and catalytic
function of KatG. Third Southeast Enzymes Conference,
Atlanta, GA.
Duan, H., and Goodwin, D. 2011. Essential role of distant interdomain interactions
in H2O2 decomposition by catalase-peroxidases. 18th
Annual Meeting of the Society for Free Radical Biology and Medicine,
Atlanta, GA.
Wang, Y., and Goodwin, D. 2011. Contribution of an ÒinactiveÓ domain to
rapid H2O2 decomposition by KatG. 18th
Annual Meeting of the Society for Free Radical Biology and Medicine,
Atlanta, GA.
Ndontsa, E. N., and Goodwin, D. C.
2011. An improvised mechanism for H2O2
disproportionation based on an old enzyme scaffold. 18th
Annual Meeting of the Society for Free Radical Biology and Medicine,
Atlanta, GA.
Ndontsa, E. N., and Goodwin, D. C.
2011. An improvised mechanism for H2O2
disproportionation based on an old enzyme scaffold. Southeast/Southwest Regional Meeting,
National Organization for the Professional Advancement of Black Chemists and
Chemical Engineers (NOBCChe), Auburn, AL (1st Place award winning
presentation)
Kudalkar, S. N., and Goodwin, D. C. 2011. Tracing the Impact of a Unique Loop in
Catalase-peroxidase Catalysis. Annual Meeting of the American Society for
Biochemistry and Molecular Biology, Washington, D. C.
Kudalkar, S. N., and Goodwin, D. C. 2011. Dependence of catalytic ability of catalase-peroxidase
on intersubunit interactions. Annual Meeting of the American Society for
Biochemistry and Molecular Biology, Washington, D. C.
Kudalkar, S. N., and Goodwin, D. C.,
2011. Effects of progressive
deletion of a unique loop on structure and function of
catalase-peroxidases. Second Southeast Enzymes Conference, Atlanta,
GA.
Wang, Y., and Goodwin, D. C. 2011. Borrowing the E. coli catalase-peroxidase C-terminal domain as a scaffold for
generation of new heme-dependent catalysts. Second
Southeast Enzymes Conference, Atlanta, GA.
Ndontsa, E., and Goodwin, D. C. 2011. Stimulation of catalase activity of
catalase-peroxidases by peroxidase reducing substrates: New functions from old scaffolds. Second
Southeast Enzymes Conference, Atlanta, GA.
Department of Chemistry, University of
South Alabama, September 10, 2010.
The transformation of enzyme function: Commandeering an old framework
for new activity.
Goodwin,
D. C., Ndontsa, E. N., and Moore, R.
2010. A new role for the
vestigial peroxidase function of KatG:
pH-dependent catalase activation.
Gordon Conference: Enzymes, Coenzymes, and Metabolic
Pathways, Waterville Valley, NH.
Kudalkar, S. N., and Goodwin, D. C. 2010. Impact of intersubunit interactions on
catalytic versatility of catalase-peroxidases. First
Southeast Enzyme Conference, Atlanta, GA.
Goodwin, D.C., Li, Y, Kudalkar, S.,
Campbell, R., and Prescott, C. 2009.
Roles of insertional sequences in commandeering an existing enzyme
framework for new catalytic function: A case study in catalase-peroxidases. Gordon
Conference: Enzymes, Coenzymes, and
Metabolic Pathways, Waterville Valley, NH.
Department of Chemistry, Georgia State
University, March 20, 2009. Structural requirements for the
hemoprotein-dependent decomposition of hydroperoxides: Lessons from the
catalase-peroxidases.
Hall, K., McCain, L., and Goodwin D. C. 2009. Antioxidants: Totally Rad! NSF
Teaching Enhancement Award Oral/Poster Session, Auburn University.
Moore, R. M., and
Goodwin, D. C. 2009. Activation of
oxygen production by reducing substrates in E.
coli catalase-peroxidase. Gordon Conference: Metals in Biology
Cook, C.O., Moore,
R.L., and Goodwin, D. C. 2008. Role
of R117 and D597 interdomain residues in the reactivation of E. coli
catalase-peroxidase. American Chemical Society, 235th National
Meeting, New Orleans, LA.
Cook, C.O., and
Goodwin, D.C. 2008. Role of the central hydrogen bonding
network interdomain residues in the bifunctionality of catalase-peroxidases. NOBCChE
35th Annual Conference, Philadelphia, PA.
Cook, C.O., Moore,
R.L., Goodwin, D.C. 2007. Effect of Distant, Intradomain Residues on Restoring
the Catalase-Peroxidase Bifunctional Active Site, Southeast Regional Meeting of the American Chemical Society,
Greenville, SC.
Moore, R.L., Williams, R., and Goodwin, D.C. 2007. Role of interdomain interaction of
tyrosine 111 on catalase-peroxidase, Southeast
Regional Meeting of the American Chemical Society, Greenville, SC.
Whitley, E.M., Goodwin, D.C.,
Cupp, M.S., Todd, L.W., Zhang, D., Mount, J.D., Powell, L.J., and Cupp,
E.W. 2007. Conformational and functional stability
and immunogenicity of a vasoactive insect salivary protein, Experimental Biology Annual Meeting,
Washington, DC.
Varnado, C.L., Olson, J.S., and
Goodwin D.C. 2007. Expression of
recombinant hemoproteins in E. coli using a heme protein expression system, 51st Annual Meeting of the
Biophysical Society, Baltimore, MD.
Goodwin,
D.C., Cook, C.O., Moore, R.L. 2007.
Roles of distant but highly conserved interactions in maintaining active
site function in catalase-peroxidases. Gordon
Conference: Enzymes, Coenzymes, and Metabolic Pathways, Biddeford, ME.
Cook,
C. O., Moore, R. L., Goodwin, D. C. 2007. Role of intrasubunit interactions
between domains in catalase-peroxidase structure and activity. American Chemical Society, 233rd
National Meeting, Boston, MA.
Department of Chemistry, Jacksonville State University, February
20, 2007. Structures and Mechanisms
of Hemoproteins: Implications for
Enzyme Engineering, Bacterial Virulence, and Antibiotic Resistance.
Goodwin,
D. C., Cook, C. O., Baker, R. D.
2006. Modulation of
catalase-peroxidase active site structure and catalysis by distant protein
structures. American Chemical Society, 231st National Meeting,
Atlanta, Georgia.
Moore,
R., Goodwin, D. C., Laband, K. A., and Powell, L. 2006. Role of interdomain salt bridge on
catalase-peroxidase activity. American Chemical Society, 231st
National Meeting, Atlanta, Georgia.
Cook,
C. O., Baker, R., and Goodwin, D. C.
2006. Function of a
gene-duplicated domain in catalase-peroxidase structure and activity. American
Chemical Society, 231st National Meeting, Atlanta, Georgia.
Department
of Chemistry and Physics, Georgia College and State University, Milledgeville,
GA, February 2006. Contribution of Protein Structural Features to the Unique
Catalytic Properties of Catalase-Peroxidases: Implications for Bacterial Virulence,
Antibiotic Resistance, and Enzyme Engineering.
Department
of Chemistry, University of West Florida, Pensacola, FL, October 21, 2005.
Contribution of Protein Structural Features to the Unique Catalytic Properties
of Catalase-Peroxidases:
Implications for Bacterial Virulence, Antibiotic Resistance, and Enzyme
Engineering.
Li,
Y., and Goodwin D. C. 2004. Central participation of an interhelical
insertion in catalase-peroxidase bifunctionality and resistance to
peroxide-dependent inactivation. Southeast
Regional Meeting of the American Chemical Society, Research Triangle Park,
North Carolina.
Baker,
R. D., Cook, C. O., and Goodwin D. C.
2004. Essential contribution
of the C-terminal domain to the structure of the catalase-peroxidase active
site. Southeast Regional Meeting of the American Chemical Society,
Research Triangle Park, North Carolina.
Cook,
C. O., Baker, R. D., and Goodwin, D. C.
2004. Catalase-peroxidase
active site restructuring by a distant and inactive domain. Southeast Regional Meeting
of the American Chemical Society, Research Triangle Park, North Carolina.
Laband, K. A., Baker, R. D., and
Goodwin, D. C. 2004. Contributions of an interdomain ion pair
to the bifunctional properties of catalase-peroxidases. Southeast
Regional Meeting of the American Chemical Society, Research Triangle Park,
North Carolina.
Varnado, C. L., and
Goodwin D. C. 2004. Heme- and peroxide-dependent formation
of a novel crosslink in catalase-peroxidases. Southeast Regional Meeting
of the American Chemical Society, Research Triangle Park, North Carolina.
Department of
Chemistry and Biochemistry, University of Delaware, Newark, DE, November 1,
2004. Protein
Structural Contributions to the Unique Catalytic Properties of
Catalase-Peroxidases.
Department of
Biochemistry, Wake Forest University, Winston-Salem, NC, August 3, 2004. Protein Structural Contributions to the Unique Catalytic
Properties of Catalase-Peroxidases.
Goodwin, D. C.,
Baker, R. D., Cook, C. O., and Laband, K. A. 2004. Integral Involvement of an Inactive
Domain in Catalase-Peroxidase Structure and Catalysis Gordon
Conference: Enzymes, Coenzymes, and
Metabolic Pathways, Meriden, NH, July 20.
Department of
Chemistry, New York University, New York, NY, April 26, 2004. Protein Structural Contributions
to the Unique Catalytic Properties of Catalase-Peroxidases.
Department of
Biochemistry, Vanderbilt University, Nashville, TN, March 26, 2004. Structural
Requirements for the Hemoprotein-Dependent Decomposition of
Hydroperoxides: Lessons from the
Catalase-Peroxidases.
Department of
Chemistry and Physics, LaGrange College, LaGrange, GA. March 10, 2004. Hemoprotein Structure and Mechanism: Implications for Enzyme
Engineering, Bacterial Virulence, and Antibiotic Resistance.
Department of
Chemistry, Butler University, Indianapolis, IN. February 18, 2004. Structural Requirements for the
Hemoprotein-Dependent Decomposition of Hydroperoxides: Lessons from the Catalase-Peroxidases.
Department of
Chemistry, Case Western Reserve University, Cleveland, OH. February 6, 2004. Structural Requirements for the
Hemoprotein-Dependent Decomposition of Hydroperoxides: Lessons from the Catalase-Peroxidases.
Department of
Chemistry and Physics, Georgia College and State University, Milledgeville,
GA. February 2, 2004. Hemoprotein Structure and
Mechanism: Implications for Enzyme Engineering, Bacterial Virulence, and
Antibiotic Resistance.
Goodwin, D. C.,
Baker, R. D., Varnado, C. L., and Li, Y.
2003. Structural
Requirements for the Hemoprotein-Dependent Decomposition of Hydroperoxides: Lessons from the
Catalase-Peroxidases. Symposium
Title: Chemistry and Biology of Oxidative
Damage. Southeast Regional Meeting
of the American Chemical Society, Atlanta, GA.
Varnado, C. L., and
Goodwin, D. C. 2003.
Characterization of a Novel Periplasmic Catalase-Peroxidase. Southeast Regional Meeting of the American
Chemical Society, Atlanta, Georgia.
Baker, R., and
Goodwin D. C. 2003. Insight into the Role of the C-Terminal Domain in
Catalase-Peroxidase Function. Southeast Regional Meeting of the American
Chemical Society, Atlanta, Georgia.
Laband, K. A., and
Goodwin D. C. 2003. Peroxidase-Catalyzed Oxidation of Plant-Derived o-Methoxyphenols: Implications for the Metabolism of
Health-Promoting Phenolic Compounds.
Southeast Regional Meeting of the
American Chemical Society, Atlanta, Georgia.
Li, Y., and Goodwin
D. C. 2003. Use of Deletion Mutagenesis to Determine the Novel Functions of Two
Unique Interhelical Insertions in Catalase-Peroxidases. Southeast
Regional Meeting of the American Chemical Society, Atlanta, Georgia.
Baker, R., and
Goodwin, D. C. 2003. Essential Role of the C-terminal Domain
in Catalase-Peroxidase Function. American Chemical Society, 226th
National Meeting, New York, NY.
Sept 9, 2003; Bioinorganic Chemistry.
Li, Y., and
Goodwin, D. C. 2003. Roles of Two Interhelical Insertions in
Catalase-Peroxidase Bifunctionality.
American Chemical Society, 226th
National Meeting, New York, NY.
Sept 9, 2003; Bioinorganic Chemistry.
Varnado, C. L.,
Hertwig, K. M., Thomas, R., Roberts, J. K., and Goodwin, D. C. 2003. Spectral
and Kinetic Properties of a Novel Periplasmic Catalase-Peroxidase. American
Chemical Society, 226th National Meeting, New York, NY. Sept 10, 2003; Biological Chemistry
Goodwin, D. C.,
Baker, R., Varnado, C. L., and Li, Y.
2003. Protein Structural Contributions to the Unique Catalytic
Properties of Catalase-Peroxidases.
Gordon Conference: Enzymes,
Coenzymes, and Metabolic Pathways, Meriden, NH, July 14-17, 2003.
Goodwin D. C. Hemoprotein Structure and Mechanism:
Implications for Enzyme Engineering, Bacterial Virulence, and Antibiotic
Resistance. Department of
Chemistry, State University of West Georgia, Carrollton, GA. April 11, 2003.
Varnado, C. L., and
Goodwin, D. C. 2002. Design of a
specialized expression system for recombinant hemoproteins. Southeast Regional Meeting of the American
Chemical Society, Charleston, South Carolina, November 14, 2002.
Baker, R., Li, Y., and
Goodwin D. 2002. Selective Elimination of Catalase Activity from
Catalase-Peroxidase by Deletion Mutagenesis. Southeast
Regional Meeting of the American Chemical Society, Charleston, South
Carolina, November 15, 2002.
Goodwin, D. C. Hemoprotein Structure and Mechanism:
Implications for Enzyme Engineering, Bacterial Virulence, and Antibiotic
Resistance. Department of Chemistry, University of Mississippi, Oxford,
MS. October 18, 2002.
Goodwin, D. C., Li,
Y., and Baker, R. 2002. Selective Elimination of Catalase
Activity from Catalase-Peroxidase by Deletion Mutagenesis. Gordon
Conference: Enzymes, Coenzymes, and Metabolic Pathways, Meriden, NH, July
23 and 24, 2002.
Hertwig, K. M., and
Goodwin, D. C. 2002.
Characterization of a novel, extracellular catalase-peroxidase from E. coli O157:H7. Council
on Undergraduate Research, Posters on the Hill Forum, Washington, D.C. April 18, 2002.
Hertwig, K. M. and
Goodwin, D. C. 2001. Cloning,
overexpression, purification, and characterization of catalase/peroxidase from
enterohemorrhagic E. coli
O157:H7. Amer. Chem. Soc. Southeast Regional Meeting, Savannah, GA.
Li, Y., Melius, P.,
and Goodwin, D. C. 2001. Activation of Bacterial Catalase-Peroxidases by
Addition of Hemin. Amer. Chem. Soc., Southeast Regional Meeting,
Savannah, GA.
Hertwig, K. and
Goodwin, D. C. 2001. Cloning,
overexpression, purification, and characterization of catalase/peroxidase from
enterohemorrhagic E. coli O157:H7. Amer. Chem. Soc. 222nd National Meeting,
Chicago, IL.
Goodwin, D. C. Catalase/Peroxidase Structure, Function,
and Kinetics: Implications for
Antibiotic Resistance and Bacterial Virulence. Department of Chemistry, State
University of West Georgia, Carollton, GA.
April 27, 2000.
Goodwin, D. C. Mechanisms of Prostaglandin
Biosynthesis: Generation and
Trapping of Tyrosyl Radicals. Department of Chemistry and Biochemistry,
University of Texas at Arlington, Arlington, TX. April 26, 1999.
Goodwin, D. C. Structure and Function of
Catalase/Peroxidases: Implications
for Antibiotic Resistance and Virulence. Department of Chemistry and
Biochemistry, University of Texas at Arlington, Arlington, TX. April 27, 1999.
Goodwin D. C. Mechanisms of Prostaglandin
Biosynthesis: Generation and
Trapping of Tyrosyl Radicals. Department of Chemistry, Auburn University,
Auburn, AL. January 29, 1999.
Goodwin, D. C. Structure and Function of
Catalase/Peroxidases: Implications
for Antibiotic Resistance and Virulence. Department of Chemistry, Auburn
University, Auburn, AL. April 26,
1999.
Goodwin, D.C.,
Rowlinson, S. W., and Marnett, L. J. 1998.
Heme oxidation states in prostaglandin endoperoxide H synthase catalytic
mechanism. Amer. Chem. Soc. 216th
National Meeting, Boston, MA.
Rowlinson, S.W.,
Crews, B. C., Goodwin D. C., and Marnett L. J. 1998. Structure/function
analysis on the cyclooxygenase channel of mouse prostaglandin endoperoxide
synthase-2. Amer. Chem. Soc. 216th
National Meeting, Boston, MA.
Goodwin, D.C.,
Gunther, M. R., Hsi, L. C., Crews, B. C., Eling, T. E., Mason, R. P., and
Marnett, L. J. 1997. Nitric oxide trapping of the Y385 radical during
prostaglandin endoperoxide synthase turnover. Intl. Congress Biochemistry Mol. Biol./Amer. Soc. Biochemistry Mol.
Biol. Joint Meeting, San Francisco, CA.
Goodwin, D. C. Kinetics of redox mediation in
peroxidase catalysis: implications
for metabolism of xenobiotics.
Department of Biochemistry, Center in Molecular Toxicology, School of
Medicine, Vanderbilt University, Nashville, TN. April 2, 1996.
Goodwin, D. C. Kinetics of redox mediation in
peroxidase catalysis: implications
for metabolism of xenobiotics.
Atherosclerosis, Nutrition, and Lipid Research Division, School of Medicine,
Washington University, Saint Louis, MO, April 4, 1996.
Goodwin, D. C. Kinetics of redox mediation in
peroxidase catalysis: implications
for metabolism of xenobiotics.
Department of Biochemistry, Michigan State University, East Lansing, MI,
April 8, 1996.
Goodwin, D.C., Aust,
S. D., and Grover, T. A. 1996. Enhancement of peroxidase-catalyzed
oxidation of hydrazine derivatives by chlorpromazine. Amer. Soc. Biochemistry Mol. Biol. National Meeting, New Orleans,
LA.
Goodwin, D.C., Aust,
S. D., and Grover, T. A. 1996. Enhancement of peroxidase-catalyzed
xenobiotic oxidation by phenothiazines. Soc.
Toxicol. Annual Meeting, Anahiem, CA.
Goodwin, D.C., Aust,
S. D., and Grover, T. A. 1995. Phenothiazines as redox mediators in
peroxidase-catalyzed xenobiotic oxidation. Soc.
Toxicol. Mountain West Chapter Annual Meeting, Ft. Collins, CO.
Goodwin, D. C.,
Yamazaki, I., Aust, S. D., and Grover, T. A. 1995. Determination of transient-state rate
constants for peroxidase reactions. Amer.
Soc. Biochemistry Mol. Biol./Amer. Chem. Soc. Div. Biol. Chem. National
Meeting, San Francisco, CA.
Goodwin, D.C., Aust,
S. D., and Grover, T. A. 1995. Redox mediators in lignin peroxidase
catalysis: A kinetic model. Amer. Soc.
Biochemistry Mol. Biol./Amer. Chem. Soc. Div. Biol. Chem. National Meeting, San
Francisco, CA.
Grover, T.A.,
Goodwin, D. C., Barr, D. P., and S.D. Aust. 1994. Protection of lignin peroxidase
activity: oxalate and cation radicals.
Intl. Soc. Free Rad. Res. 7th Biennial Meeting, Sydney, Australia.
Goodwin, D.C., Aust,
S. D., and Grover, T. A. 1994. Veratryl alcohol (VA) mediated oxidation
by lignin peroxidase. Intl. Soc. Free
Rad. Res. 7th Biennial Meeting, Sydney, Australia.
Goodwin, D.C., Barr,
D. P., Aust, S. D., and Grover, T. A.
1994. Inactivation of lignin
peroxidase of Phanerochaete chrysosporium
by oxygen radicals. Amer. Soc. for
Microbiol. 94th General Meeting, Las Vegas, NV.
Goodwin, D. C.,
Barr, D. P., Aust, S. D., and Grover, T. A. 1994. The novel role of the fungal metabolite
oxalate in the catalytic cycle of lignin peroxidase. Amer. Soc. Microbiol.
Intermountain Branch Annual Meeting, Provo, UT.
Goodwin, D. C.,
Johnston, C. G., Aust, S. D., and Grover, T. A. 1993. Microwave extraction of DNA from fungi
in soil: a simple, rapid method for polymerase chain reaction. Amer. Soc. Microbiol., 93rd General Meeting,
Atlanta, GA.
Johnston, C.G.,
Goodwin, D. C., and Aust, S. D. 1994. Use of ribosomal DNA for species
delineation and detection of
Phanerochaete spp. Amer. Soc. Microbiol. 94th General Meeting, Las Vegas,
NV.
Goodwin, D.C., and
Lee, S. B. 1992. Ribosomal DNA sequences of Leptomitus
lacteus, Sapromyces elongatus, Aquilinderella fermentans, and Rhipidium sp. and their evolutionary implications for the
Oomycete order Leptomitales. Soc. Study
Evol., University of California, Berkeley, CA.
National Institutes of Health (R15 AREA) (under review)
PIs: Calderon, A. and Goodwin, D.C.
Dates: 07/01/18 -
06/30/21
Toward New Antitubercular Drugs: Uncovering Mechanistically
Appropriate Inhibitors of Mycobacterium tuberculosis Shikimate
Kinase from Natural Products.
Amount: $440,000
National Science Foundation (MCB 1616059)
PI: Goodwin, D.
C.
Dates: 08/01/16 – 07/31/19
Conduits and Control of KatG Intramolecular Electron
Transfer: Formation and Operation of a Novel Cofactor
Ammount: $569,549
Intramural Grants Program (2012-3-2-Calderon)
PI: Calderon, A.
Dates: 3/1/13
– 2/28/15
Toward New Antitubercular Drugs: Uncovering Mechanistically
Appropriate Inhibitors of Mycobacterium tuberculosis Shikimate Kinase
from Natural Products
Amount: $54,000
Competitive Outreach Scholarship Grant
PI:
Stevens, K.
Dates: 3/1/13 – 2/28/14
Bridging the Curriculum Gap in Prisoner Education: A
Collaboration of Colleges Innovating Solutions
Amount: $59,568
National Science Foundation (MCB-0641614)
PI: Goodwin, D.
C.
Dates: 7/1/07
– 6/30/12
Indispensable Roles of an Inactive Domain in
Catalase-Peroxidase Catalysis:
Applications for Enzyme Engineering
Amount: $434,184
National Science Foundation (MCB-0641614 - supplement)
PI: Goodwin, D. C.
Dates: 7/1/09 – 6/30/10
Title: Indispensable Roles of an Inactive Domain in Catalase-Peroxidase Catalysis: Applications for Enzyme Engineering (Supplement)
Amount: $25,353
United States Department of
Agriculture, Hatch Grant and Alabama Agricultural Experiment Station Special
Grants Program.
PD: Elizabeth Whitley. Co-PDs: Dwight Wolfe, M Edmonson, Douglas C.
Goodwin, , Development of Vaccines Targeting Horn Flies
USDA CSREES Special Research Grants
PI: Wolfe, D.
Co-PIÕs: Goodwin, D. C.,
Whitley, E., and Abrams, M.
Dates:
8/1/06 – 7/31/07)
Evaluation of a Horn Fly Polyvalent Vaccine for Cattle
A protective vaccine for cattle against horn flies is being
developed. The antigens are derived
from salivary proteins produced by this insect. The Goodwin group is using CD and other
techniques to evaluate structure and stability of the component proteins and
gain insight into the function of these proteins in blood feeding.
Role: Co-PI
PRISM 2004
PI: Goodwin, D.
C. Co-PIÕs: Ellis, H. R., Duin, E. C., Striegler,
S., and Singh, N.
Dates: 4/1/04 –
3/31/05
Circular Dichroism at Auburn University
Funds were requested for the purchase of a circular
dichroism spectropolarimeter with Peltier temperature control system and
autotitration system.
Role: Principal
Investigator
PRF
# 38802 – G4 PI: Goodwin, D. C. Dates: 1/1/2003 – 9/30/2005
Understanding the
Bifunctional Active Site of Catalase-Peroxidases: Insights for Enzyme
Engineering.
In these studies,
deletion mutagenesis is used to identify the role of catalase-peroxidase-unique
structural components in the bifunctional catalytic abilities of
catalase-peroxidases.
Role: Principal
Investigator
Biogrant 2-1319200 PI: Goodwin, D. C. Dates 5/1/2001 – 4/30/2003
Alabama Biogrant
through Auburn University
Mechanisms of Heme
Acquisition by Enterohemorrhagic E. coli
strain O157:H7.
In these studies,
investigators seek to evaluate the influence of perturbations in heme structure
on heme binding by a receptor isolated from enterohemorrhagic E. coli.
Role: Principal Investigator
Current:
Rene Fuanta Ngolui,
Ph.D. Candidate, Chemistry, Project: Mechanistically appropriate inhibitors of M. tuberculosis shikimate kinase for
development of new antitubercular agents.
Hui Xu, Ph.D. Student,
Chemistry, Project: Stimulation of bacterial and fungal peroxide defenses by
peroxidatic electron donors.
Jessica Krewall,
Ph.D. Candidate, Chemistry, Project: Pathways of intramolecular electron
transfer in KatG: Implications for catalytic function and bacterial defenses
against peroxides.
Tarfi Aziz, Ph.D.
Student, Chemistry, Project: Intramolecular electron transfer processes in
formation of the Met-Tyr-Trp protein-based cofactor of KatG.
Callie Jackson,
Ph.D. Student, Chemistry, Project: TBA
Rejaul Islam, Ph.D.
Student, Chemistry, Project: TBA
Previous:
Dr. Olive Njuma, Ph.D. Graduate,
Chemistry, Dissertation Title: Resolving
the paradoxical nature of a bifunctional enzyme: Pathways and regulation of
intramolecular electron transfer in KatG. Defense date: June 2, 2016.
Current Position: Postdoctoral Associate, Vanderbilt University School of
Medicine.
Dr. Haijun Duan, Ph.D. Graduate,
Chemistry, December 2014. Dissertation Title: KatG as a defense against
hydrogen peroxide toxicity: from a redundant C-terminal domain to the
paradoxical synergy of two mutually antagonistic activities. Defense date: November 10, 2014.
Current Position: Postdoctoral Associate, University of Kentucky.
Dr. Elizabeth
Ndontsa, Ph.D. Graduate, Chemistry, Dissertation Title: Synergy not antagonism in antioxidant defenses: the unanticipated
effect of electron donors on catalase-peroxidase function. Defense date:
March 20, 2013. Current Position: Research Associate, Aduro Biotech, Inc.
Dr. Yu Wang, Ph.D.
Graduate, Chemistry, Dissertation Title: Gene
Duplication and Fusion: Strategy for Active Site Control and Starting Point for
New Catalysts. Defense date: November 6, 2012. Current Position: Assistant
Professor, University of North Georgia.
Dr. Shalley
Kudalkar, Ph.D. Graduate, Chemistry, Dissertation Title: Roles of Large Loops in Catalytic Versatility of
Catalase-Peroxidases: Significance
of Peripheral Structures in Impovising Enzyme Functions. Defense Date: December 16, 2011. Current Position: Postdoctoral Associate, Yale University,
Nashville, TN.
Dr. Carma O. Cook,
Ph.D. Graduate, Chemistry, Dissertation Title: Role of Distant Intrasubunit Residues in
Catalase-peroxidase Catalysis: Tracing
the role of gene duplication and fusion in enzyme structure and function. Defense Date: December 4, 2008.
Dr. Robert Moore,
Ph.D. Graduate, Chemistry, Dissertation Title: Toward the understanding
of complex biochemical systems: the
significance of global protein structure and thorough parametric analysis. Defense Date: May 26, 2009. Current Position: Assistant Professor,
Wayland Baptist University, Wayland, TX.
Dr. Ruletha Baker,
Ph.D. Graduate, Chemistry, Dissertation Title: Roles
of an inactive domain in in catalase-peroxidase catalysis: Modulation of active
site architecture and function by gene duplication. Defense date: August 14, 2006.
Dr. Cornelius
Varnado, Ph.D. Graduate, Chemistry, Dissertation Title: Enhancing
expression of recombinant hemoproteins: Progress toward understanding
structure/function and therapeutic application. Defense date: June 29, 2006.
Ronald Marcy, GND
Graduate Student, Chemistry, Project:
Structure and function of catalase-peroxidases. Progress: Ron is an instructor at Alabama Southern
Community College who worked in the laboratory to get exposure to the latest
techniques in biochemistry and molecular biology in order to enhance teaching
of his chemistry and microbiology courses.
Trey Slaney, Ph.D. Student, Chemistry, Major Professor: Dr. Steven
Mansoorabadi
Kenny Nguyen, Ph.D. Student, Chemistry, Major Professor: Dr.
Steven Mansoorabadi
Richard Hagen, Ph.D. Student, Chemistry, Major Professor: Dr.
Holly Ellis
Qi Cui, Ph.D. Student, Chemistry, Major Professor: Dr. Jordan
Harshman
Kiayuan Zheng, Ph.D. Candidate, Chemistry, Major Professor: Dr.
Steven Mansoorabadi
Juan Hu, Ph.D. Candidate, Chemistry, Major Professor: Dr. Chris
Easley
Dianna Forbes, Ph.D. Candidate, Chemistry, Major Professor: Dr.
Holly Ellis
Claire Graham, Ph.D. Candidate, Chemistry, Major Professor: Dr.
Holly Ellis
Katie Stanford, Ph.D. Candidate, Chemistry, Major Professor: Dr.
Holly Ellis
Carly
Engel, Ph.D. Candidate, Chemistry, Major Professor: Dr. Eduardus Duin
Victoria Owens, Ph.D. Candidate, Chemistry, Major Professor: Dr.
Steven Mansoorabadi
Marike Visser, Ph.D.
Graduate, Veterinary Medicine, Major Professor: Dr. Dawn Boothe (outside
reader)
Jonathan Musila,
Ph.D. Graduate, Chemistry, Major Professor: Dr. Holly Ellis
Selamawit Ghebreamlak, Ph.D. Graduate,
Chemistry, Major
Professor: Dr. Evert Duin
Johayra Simithy, Ph.D. Graduate, Drug
Discovery and Development, Major Professor:
Dr. Angela Calderon (outside reader)
Paritosh Dayal, Masters
Graduate, Chemistry, Major Professor: Dr. Holly Ellis
Meng
Yu, Ph.D. Graduate, Chemistry, Major Professor: Dr. Chris Goldsmith
Jiansheng
Huang, Ph.D. Graduate, Pharmacal Sciences, Major Professor: Dr. Peter Panizzi
Divya
Prakash, Ph.D. Graduate, Chemistry, Major Professor: Dr. Eduardus Duin
Brian
Ferguson, Ph.D. Graduate, Health and Human Performance, Major Professor: Dr.
Bruce Gladden
Qiao
Zhang, Ph.D. Graduate, Chemistry, Major Professor: Dr. Chris Goldsmith
John
ÒMickÓ Robbins, Ph.D. Graduate, Chemistry, Major Professor: Dr. Holly Ellis
Catherine Njeri,
Ph.D. Graduate, Chemistry, Major Professor: Dr. Holly Ellis
Matthew Barberio,
Ph.D. Graduate, Health and Human Performance, Major Professor: Dr. David Pascoe
Jingyuan Xiong,
Ph.D. Graduate, Chemistry, Major Professor: Dr. Holly Ellis
Chengdong Huang,
Ph.D. Graduate, Chemistry, Major Professor: Dr. Smita Mohanty
Erin Imsand, Ph.D. Graduate,
Chemistry, Major Professor: Dr. Holly Ellis
Weiya Xu, Ph.D. Graduate,
Chemistry, Major Professor: Dr. Evert Duin
Jody Burks, Ph.D. Graduate,
Animal Science, Major Professor:
Dr. Jacek Wower
Russell Carpenter,
Ph.D. Graduate, Chemistry, Major Professor: Dr. Holly Ellis
Sidharth Venkatesh,
Ph.D. Graduate, Chemical Engineering, Major Professor: Dr. Mark Byrne
Trafina Jadhav,
Ph.D. Student, Biological Sciences, Major Professor: Dr. Marie Wooten
(resigned)
Matthew Goodwin,
Ph.D. Graduate, Health and Human Performance, Major Professor: Dr. Bruce
Gladden
Mi Wang, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. Evert Duin
Xuanzhi Zhan, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. Holly Ellis
Weikuan Li, Ph.D.
Graduate, Chemistry, Major Professor: Dr. Stewart Schneller
Rajesh Gupta, Ph.D.
Graduate, Chemical Engineering, Major Professor: Dr. Yoon Lee
John-Ryan McAnnally,
M.S. Graduate, Biological Sciences, Major Professor: Dr. James Bradley
James Harris, Ph.D.
Candidate, Health and Human Performance, Major Professor: Dr. Bruce Gladden
(resigned)
Kholis Abdurachim,
Ph.D. Graduate, Chemistry Major Professor:
Dr. Holly Ellis
Dolapo Adedji, Ph.D. Graduate, Chemistry, Major
Professor: Dr. Evert Duin
Na Yang, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. Evert Duin
Honglei Sun, M.S.
Graduate, Chemistry, Major Professor:
Dr. Holly Ellis
Benlian Gao, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. Holly Ellis
Ling Tang, Ph.D.
Graduate, Animal Science, Major Professor:
Dr. Werner Bergen
Rong Wu, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. S. D. Worley
Wei Ye, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. Stuart Schneller
Darcy Goodwin, Masters Graduate,
Animal and Dairy Sciences, Major Professor: Dr. Skip Bartol
Amanda Bean, Ph.D.
Graduate, Chemistry, Major Professor:
Dr. Thomas Albrecht-Schmitt
Ben Stronach,
Masters Graduate, Animal and Dairy Sciences, Major Professor: Dr. Werner Bergen
Wendy White, Masters
Graduate, Biological Sciences, Major Professor: Dr. Marie Wooten
Chunru Lin, Ph.D.
Student (resigned), Biology, Major Professor: Dr. Marie Wooten
BCHE
7220 Principles of Cellular and Molecular Enzymology
CHEM
640 Biochemistry
CHEM
7950 Biochemistry Seminar
CHEM 7930 Directed
Individual Study
CHEM
7750 Formal Presentations in Chemistry
Savannah Petrus, Undergraduate (BS, Biochemistry) Auburn
University; January 2018 – present.
Kirklin McWhorter, Undergraduate (BS, Biochemistry) Auburn
University; May 2017 – present. (Haggard Undergraduate Research Fellow,
2018 – 2019; CMB Undergraduate Research Fellow, Summer 2017).
Patrick Sahrmann, Undergraduate (BS, Biochemistry) Auburn
University; August 2016 – present. (Auburn University Undergraduate
Research Fellow (2017 – 2018) Marks Family Scholar, 2016 – 2018).
Michael Skinner,
Undergraduate (Junior, Biomedical Sciences) Auburn University; January 2015
– May 2015; August 2015 – December 2016. (CMB Undergraduate
Research Fellow, Summer 2016)
Olivia Snider, Undergraduate
(Senior, Biochemistry) Auburn University; May 2015 – May 2016. (CMB
Undergraduate Research Fellow, Summer 2015; Marks Family Scholar, 2015 –
2016).
Theresa Simermeyer, Undergraduate
(Senior, Biochemistry) Auburn University; May 2015 – May 2016.
Daniel Zieman, Undergradaute
(Senior, BA Chemistry) Auburn University; August 2015 – October 2015.
Moneisha Cunningham,
Undergraduate (Senior, BA Chemistry) Auburn University; January 2015 –
June 2015.
Alex Kollhoff, Undergraduate
(Senior, Biomedical Sciences) Auburn University; May 2014 – January 2015.
(CMB Undergraduate Research Fellow, Summer 2014)
Lauren Barr, Undergraduate
(Graduated, Biomedical Sciences) Auburn University; January 2014 – May
2015. (Marks Family Scholar, 2014 -2015)
Teddy Childers, Undergraduate
(Senior, Biomedical Sciences) Auburn University; January 2014 – January
2015.
Ethan McCurdy, Undergraduate
(Graduated, Chemistry) Auburn University; January 2013 – June 2014.
(Auburn University Undergraduate Research Fellow, 2013 -2014)
Gobind Gill, Undergraduate (Graduated,
Biochemistry) Auburn University, June 2012 – July 2014. (CMB
Undergraduate Research Fellow, Summer 2013; Honors Thesis)
R. Elliott Browning, Undergraduate
(Graduated, Biomedical Sciences) Auburn University; January 2013 –
December 2013.
Jennifer Lewis, Undergraduate
(Graduated, Biomedical Sciences) Auburn University, June 2012 – May 2013.
Benjamin Jackson,
Undergraduate (Graduated, Biomedical Sciences) Auburn University, May 2011
– May 2012
Jordan Suh, Undergraduate
(Graduated, Chemistry) Auburn University, January 2011 – May 2012. (CMB
Undergraduate Research Fellow, Summer 2011)
Kristen Henninger,
Undergraduate (Graduated, Chemistry) Auburn University, August 2010 – May
2011.
Kendall Walton, Undergraduate
(Chemistry) Auburn University, August 2010 – May 2011.
Sara Ransom, Undergraduate
(Graduated, Biomedical Sciences) Auburn University, May 2010 – May 2011.
(Honors Thesis)
Thomas Townes, Undergraduate
(Graduated, Biomedical Sciences) Auburn University, August 2010 –
December 2010.
Ryan Tucker, Undergraduate
(Graduated, Biochemistry) Auburn University, August 2009 – July, 2010.
John Pribonic, Undergraduate
(Graduated, Biochemistry) Auburn University May 2009 – July 2010.
Kendall Hall, High School
Student, Auburn University Cellular and Molecular Biosciences Teaching
Enhancement Program, June 2009.
Lynn McCain, High School
Teacher, Auburn University Cellular and Molecular Biosciences Teaching
Enhancement Program, June 2009.
Michael Dumas, Undergraduate
(Graduated, Biomedical Sciences) Auburn University, May 2009 – August
2009.
Corey Prescott, Undergraduate
(Graduated, Chemistry) Auburn University, January 2009 – May 2009.
Robert Andrew Campbell,
Undergraduate (Graduated, Biochemistry) Auburn University, May 2008 – May
2009. (CMB Undergraduate Research Fellow, Summer 2008)
JaRyce Nabors, Undergraduate
(Graduated, Biochemistry) Auburn University, August 2007 – May 2008.
Michelle Muldowney,
Undergraduate (Graduated, Biochemistry) Auburn University, August 2007 –
December 2008.
Joey Russel,
Undergraduate (Biomedical Sciences) Auburn University; January 2008 – May
2008.
W. C. (Dub) Davison,
High School Student (Senior, McAdory High School) Auburn University Cellular
and Molecular Biosciences Teaching Enhancement Program, June 2007.
Jessica Williams,
Undergraduate (Graduated, Chemistry), Auburn University; May 2007 –
August 2007.
Michael Love,
Undergraduate (Graduated, Chemistry), Auburn University; January 2007 –
December 2007 (excluding summer months).
JaRyce Nabors,
Undergraduate (Graduated, Biochemistry) Auburn University; May 2006 –
August 2006. (EPSCoR Undergraduate
Summer Research Fellow)
Jennifer Smith,
Undergraduate (Graduated, Biochemistry), Auburn University; January 2006
– May 2006.
Allan Bagget,
Undergraduatee (Graduated, Biomedical Sciences), Auburn University; January
2006 – May 2006.
Grant Nelson,
Undergraduate (Graduated, Microbiology), Auburn University; January 2007
– March 2007.
Rachel Williams,
Undergraduate (Graduated, Chemistry), Auburn University; January 2007 – December
2007.
Justin Alex Taylor,
Undergraduate (Graduated, Chemistry), Auburn University; August 2006 –
December 2006.
Luke Powell,
Undergraduate (Graduated, Biomedical Sciences), Auburn University; August 2005
– August 2006. COSAM Research
Fellow
Kimberley Laband,
Undergraduate (Graduated, Molecular Biology), Auburn University; May 2002
– May 2005.
Daniel Carter,
Undergraduate (Graduated, Biomedical Sciences), Auburn University, August 2004
– December 2004.
Byron Smith, Undergraduate (Graduated,
Biomedical Sciences), Auburn University, August 2004 – December 2004.
Stephen Pehler, Undergraduate (Graduated,
Molecular Biology), Auburn University; April 2004 – October 2004.
Tyson Kilpatrick,
Undergraduate (Graduated, Biomedical Sciences), Auburn University; January 2004
– May 2004.
Greyson McGowin,
Undergraduate (Graduated, Biomedical Sciences), Auburn University; May 2003
– September 2003. CMB Research Fellow
Derek Fortson, Undergraduate (Graduated,
Biochemistry), Auburn University; August 2002 – May 2003.
Sarah Peaslee
Undergraduate (Graduated, Biochemistry), Auburn University; June 2002 –
May 2003.
Melanie Oliver,
Undergraduate (Graduated, Microbiology) Auburn University; May 2002 –
December 2002.
J. Kenneth Roberts,
Undergraduate (Graduated, Biomedical Sciences), Auburn University; June 1, 2002
– May 10, 2003.
Robert Thomas,
Undergraduate, Asbury College, Wilmore, KY.; May 15, 2002 – August 15 2002.
Kristin Hertwig,
Undergraduate (Graduated, Biochemistry), Auburn University; January 15, 2000
– December 2002.
Erika Schansberg, Undergraduate
(Graduated, Microbiology), Auburn University; August 2001 – May
2002.
Thomas Cash,
Undergraduate (Graduated, Chemistry), Auburn University; January 2002 –
May 2002.
Matthew McIntyre, Undergraduate
(Graduated, Biomedical Sci.), Auburn University; May 2001 – August
2001.
Nancy Ruth Wilkins,
Undergraduate (Graduated, Biochemistry), Auburn University; May 2001 –
August 2001.
Emily Brantley,
Undergraduate (Graduated, Molecular Biology), Auburn University; June 2000
– December 2001.
Juan Carmona,
Undergraduate (Graduated, Molecular Biology), Auburn University; August 2000
– May 2001.
Amy Wainwright,
Undergraduate (Graduated, Biochemistry), Auburn University; January 4, 2000
– June 6, 2000.
Randy Booth,
Undergraduate (Graduated, Biochemistry) Utah State University; May 20, 1996
– August 20, 1996.
Joseph Benson,
Undergraduate (Graduated, Biochemistry) Utah State University; May 20, 1995 -
May 20, 1996.
Curtis Takemoto, Undergraduate
(Graduated, Political Science) Utah State University; May 20, 1994 – May
20, 1996.
L. Undergraduate Courses Taught (*Graduate
Students Enrolled From Other Depts.)
*BCHE 5180/6180
General Biochemistry I
*BCHE 5190/6190
General Biochemistry II
BIOL
4980 Undergraduate Research
CHEM
4901 Special Problems in Chemistry
CHEM
4950 Undergraduate Seminar
CHEM
1030 Fundamentals of Chemistry I
CHEM
1020 Survey of Chemistry II
SCMH
1010 Concepts of Science
M. Outreach
SPARKs Faculty Prison Lecture Series – Staton Prison,
Elmore AL, April 20, 2018, Proteins,
Radicals, Vitamins, and Minerals: How Biology Makes Metabolism Work.
SPARKs Faculty Prison Lecture Series – Staton Prison,
Elmore AL, Spring 2018. Assisted in recruiting faculty presenters for the
series and establishing the presentation schedule.
SPARKs Faculty Prison Lecture Series – Tutwiler Prison,
Wetumpka AL, March 13, 2017, How Cells
Make Molecules that Work: Sensors, Pumps, Motors, and Power Generators.
SPARKs Faculty Prison Lecture Series – Tutwiler Prison,
Wetumpka AL, Spring 2017. Assisted in recruiting faculty presenters for the
series and establishing the presentation schedule.
Summer Bridge Program: Hands on Undergraduate Research
Demonstration – Auburn University, 6/23/16. See description below.
SPARKs Faculty Prison Lecture Series – Easterling Prison,
Clio AL, March 28, 2016, Protein
Structure and Function: Building and Managing Catalysts for Life.
SPARKs Faculty Prison Lecture Series – Easterling Prison,
Clio AL, Spring 2016. Assisted in recruiting faculty presenters for the series
and establishing the presentation schedule.
Summer Bridge Program: Hands on Undergraduate Research
Demonstration – Auburn University, 6/11/15. See description below.
Summer Bridge Program: Enhancing your undergraduate education and
experience through research, 6/10/15. See
description below.
SPARKs Faculty Prison Lecture Series – Staton Prison,
Elmore AL, February 26, 2015, Protein
Structure and Function: Building and Managing Catalysts for Life.
SPARKs Faculty Prison Lecture Series – Staton Prison,
Elmore AL, Spring 2015. Assisted in recruiting faculty presenters for the
series and establishing the presentation schedule.
Summer Bridge Program: Hands on Undergraduate Research Demonstration – Auburn
University, 6/17/14. See
description below.
Summer Bridge Program: Enhancing your undergraduate education and
experience through research, 6/13/14. See
description below.
SPARKs II Faculty Prison Lecture Series – Easterling
Prison, Clio AL, 2/12/14, 2/19/14, and 2/26/14. An expansion of the SPARKs series where
three faculty make three presentations each. Building Biology from the Ground Up: Atoms to Molecular Pumps and Power
Generators, Parts I, II, and III.
SPARKs Faculty Prison Lecture Series – Elmore Prison, Elmore AL, 2/13/14
(lecture) Protein Structure and Function:
Building and Managing Catalysts for Life. In addition, 3/6/14, 4/3/14, and
4/10/14 (new faculty guide). Participating
as a lecturer in the series as well as accompanying new faculty to the facility
for their presentations.
Auburn University Competitive Outreach Grant (Co-PI) Bridging the Curriculum Gap in Prisoner Education: A
Collaboration of Colleges, 3/13 – 2/14. The purpose of the grant is to
establish a mathematics course for and a general science course for Alabama
Prisoners using iPads as a foundational teaching tool. In addition, the grant
is to support a SPARKs lecture series, and establish the SPARKs II-type lecture
series.
Summer Bridge Program: Hands on Undergraduate Research Demonstration – Auburn
University, 6/18/13. See
description below.
Summer Bridge Program: Enhancing your undergraduate education and
experience through research, 6/15/13. See
description below.
SPARKs Faculty Prison Lecture Series – Staton Prison, Elmore, AL
(3/26/13) ÒBuilding Biology from the Ground Up: Atoms to Molecular Pumps
and Power Generators
Summer Bridge Program: Hands on undergraduate research
demonstration – Auburn University, AL (6/20/12). Students participate in
a redox biochemistry experiment. The results are visually colorful/striking,
and the materials used are enzymes that have been produced by undergraduates
working in the Goodwin Laboratory. This is intended to emphasize the importance
of involvement in research as undergraduates and is a follow-up to the research
Q and A session/lecture described below.
Summer Bridge Program: Enhancing
your undergraduate education and experience through research – Auburn
University, AL (6/13/12). The
Summer Bridge Program is designed to assist incoming COSAM freshmen from groups
underrepresented in STEM careers to make the transition to the collegiate
environment. It is a Summer minimester of courses that also teaches good study
habits to help increase the success in undergraduate study and graduation. The purpose of this particular Q and A
session/lecture is to encourage participation of these incoming undergraduates
in research programs as their academic programs progress. It is anticipated
that promotion of research activities to Summer Bridge participants as they
enter the university will lead to their application for fellowships later in
their undergraduate programs.
SPARKs Faculty Prison Lecture Series – Elmore Prison, Elmore, AL (3/12/12). Building Biology from the Ground Up: Atoms to Molecular Pumps and Power Generators. This is a lecture series presented by faculty from the Colleges of Agriculture and Sciences and Mathematics. The target audience is prisoners in the Alabama Department of Corrections System.
Biochemistry in the Kitchen – (Spring 2011) Devised and implemented a
set of experiments in enzyme isolation and kinetic evaluation using materials
commonly available at the grocery store (horseradish root, hydrogen peroxide,
vinegar, liquid laundry detergent, etc.).
Home school students performed the experiments making qualitative
evaluations in their own kitchens. The students then came to the Goodwin lab to
work with laboratory reagents and instrumentation to do parallel experiments.
Teaching Enhancement Award – Kendall Hall (High School Student);
Lynn McCain (High School Science Teacher), Project Title: ÒAntioxidants:
Totally Rad!Ó (6/09). A description of the Teaching Enhancement Award is given
below.
Science Olympiad (Spring 2009) – Co-Event Supervisor Middle School Science
Olympiad.
Science Olympiad (Spring 2008) – Developed and implemented Food Science
Event Experiments for High School and Middle School Science Olympiad.
Teaching Enhancement Award – William ÒDubÓ Davison (High School
Student); Warren Hamm (High School Chemistry Teacher), Project Title: ÒRadical
Approach to Evaluating and Teaching Kinetics of AntioxidantsÓ (6/07). The TEA project is administered through
the Auburn University Cellular and Molecular Biosciences Program. The project
brings a student/teacher pair to the laboratory of an Auburn faculty
member. The student works for two
weeks with the faculty member developing techniques and a project. The teacher joins for the third week and
the student teaches the teacher.
The goal is to develop experiments which can be translated back to the
high school classroom.
Community College Instructor Laboratory Training (2003) –
Participant: Dr. Ronald Marcy, Division Chair, Biology and Chemistry, Alabama
Southern Community College. Dr.
Marcy spent several weekends in the Goodwin laboratory learning techniques of
site-directed mutagenesis, recombinant protein expression, protein
purification, and enzymatic characterization. He then used this information to alter
lecture and laboratory courses at his home institution.