Department of Chemistry and Biochemistry
Auburn University
Auburn, AL 36830
Ph.D.,
Biochemistry, Department of Chemistry and Biochemistry, Utah State University,
August 1996, Thesis: Redox
Mediation in Peroxidase-Catalyzed Oxidation
B.A., Food,
Nutrition, and Dietetics; Minor: Chemistry; University of Northern Colorado,
December 1991, Magna Cum Laude
Associate Professor,
Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, August
2005 – present
Assistant Professor,
Department of Chemistry, Auburn University, Auburn, AL, September 1999 –
July 2005
Golden Key National Honor Society Teaching Award. Golden Key
Honor Society, Auburn University Chapter, April 2001.
Center in Molecular Toxicology Postdoctoral Research
Trainee. Department of Biochemistry, Vanderbilt University School of
Medicine, July 1998 – August 1999.
Thomas F. Emery Memorial Research Scholar. Department of Chemistry and Biochemistry, Utah State University, May 1995.
Willard L. Eccles Family Foundation Fellow. College of
Science, Utah State University, October 1992- September 1995.
George H. and Billie Bush Emert Scholar. Department
of Chemistry and Biochemistry, Utah State University, May 1996.
E.L. and Inez Waldron Travel Award.
Biotechnology Ctr, Utah State University, June 1996.
26. Moore, R.L., Cook, C.O.,
Williams, R., and Goodwin, D. C.
2008. Substitution of strictly conserved Y111 in
catalase-peroxidase: Impact of
remote interdomain contacts on active site structure and catalytic
performance. J. Inorg. Biochem. 102,
1819 – 1824.
25. Cook, C.O., Moore, R.L., and Goodwin, D.C. 2008. The effect of R117 and D597 interdomain residue substitutions on the reactivation of Escherichia coli catalase-peroxidase. NOBCChE Proceedings 35, (in press).
24. Moore, R.L., Powell, L.J., and Goodwin, D. C. 2008. The kinetic properties producing the perfunctory pH profiles of catalase-peroxidases. Biochim. Biophys. Acta. 1784, 900 – 907.
23. Trostchansky, A., O¹Donnell, V.B., Goodwin, D.C., Landino, L.M., Marnett, L.J., Radi, R., and Rubbo, H. 2007. PGHS-1 in turnover is inactivated by peroxynitrite derived- radicals: Differential effect of ·NO on peroxidase and cyclooxygenase activities. Free Rad. Biol. Med. 41, 1029 – 1038.
22. Baker, R. D.,
Cook, C. O., and Goodwin, D. C. 2006.
Catalase-peroxidase active site restructuring by a distant an inactive
domain. Biochemistry 45, 7113-7121.
21. Goodwin, D. C., Laband, K. A., and Hertwig, K. M. 2005. Capsaicinoid oxidation by peroxidases: kinetic, structural, and physiological
considerations. In Phenolics in
Foods and Natural Health Products. Ho, C. T., and Shahidi, F.,
Eds. ACS Symposium Series, Vol. 909, pp.
161-174.
20. Baker, R. D.,
Cook, C. O., and Goodwin, D. C.
2004. Properties of
catalase-peroxidase lacking its C-terminal domain. Biochem. Biophys. Res. Comm. 320, 833-839.
19. Li, Y., and
Goodwin, D. C. 2004. Vital roles
of an interhelical insertion in catalase-peroxidase bifunctionality. Biochem.
Biophys. Res. Comm. 318, 970-976.
18. Varnado,
C. L., and Goodwin, D. C.
2004. System for the
expression of recombinant hemoproteins in Escherichia coli. Prot. Exp. Purif. 35, 76-83.
17. Varnado,
C. L., Hertwig, K. M., Thomas, R., Roberts, J. K., and Goodwin, D. C.
2004. Properties of a novel
periplasmic catalase-peroxidase from Escherichia coli O157:H7.
Arch. Biochem. Biophys.
421, 166-174.
16. Goodwin, D.C., and Hertwig, K. M.
2003. Peroxidase-catalyzed
oxidation of capsaicinoids:
Steady-state and transient-state kinetic studies. Arch. Biochem. Biophys. 417, 18-26.
15. Goodwin, D.C., Rowlinson, S. W., and
Marnett, L. J. 2000. Substitution of tyrosine for the
proximal histidine ligand to the heme of prostaglandin endoperoxide
synthase-2: Implications for the
mechanism of cyclooxygenase activation and catalysis. Biochemistry 39,
5422-5432.
14. Kiefer, J. R., Pawlitz, J. L., Moreland, K. T., Stegeman, R. A., Hood, W. F., Gierse, J. K., Stevens, A. M., Goodwin, D. C, Rowlinson, S. W., Marnett, L. J., Stallings, W. C., and Kurumbail, R. G. 2000. Structural insights into the stereochemistry of the cyclooxygenase reaction. Nature 405, 97-101.
13. Rowlinson, S. W., Crews, B. C., Gierse,
J. K., Goodwin, D. C. and Marnett, L. J. 2000. Spatial requirements for 15-HETE synthesis within the
cyclooxygenase active site of murine COX-2: why acetylated COX-1 does not synthesize 15-R-HETE. J. Biol. Chem. 275, 6586-6591.
12. Goodwin, D. C., Landino, L. M., and Marnett, L. J. 1999. Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis. FASEB J. 13, 1121-1136.
11. Goodwin, D. C., Landino, L. M., and Marnett, L. J. 1999. Reactions of prostaglandin endoperoxide synthase with nitric oxide and peroxynitrite. Drug Metabolism Reviews 31, 273-294.
10. Marnett, L. J., Rowlinson, S. W., Goodwin, D. C., Kalgutkar,
A. S., and Lanzo, C. A. 1999. Arachidonic acid oxygenation by COX-1
and COX-2: Mechanisms of catalysis and inhibition. J. Biol. Chem.
274,
22903-22906.
9. Marnett, L. J., Goodwin, D. C.,
Rowlinson, S. W., Kalgutkar, A. S., and Landino, L. M. 1999. Structure, function, and inhibition of prostaglandin endoperoxide
synthase. In Comprehensive Natural Products Chemistry, Vol. V pp. 225-261. C.D. Poulter, Ed. Elsevier Science,
Amsterdam.
8. Goodwin, D. C., Gunther, M. R., Hsi, L.
C., Crews, B. C., Eling, T. E., Mason, R. P., and Marnett, L. J. 1998. Nitric oxide trapping of tyrosyl radicals generated during
prostaglandin endoperoxide synthase turnover: detection of the radical
derivative of tyrosine 385. J. Biol. Chem. 273, 8903-8909.
7. Goodwin, D. C., Grover, T. A., and
Aust, S. D. 1997. Roles of efficient substrates in
peroxidase-catalyzed oxidations. Biochemistry 36, 139-147.
6. Goodwin, D. C., Grover, T. A., and
Aust, S. D. 1996. Redox mediation in the
peroxidase-catalyzed oxidation of aminopyrine: possible implications for
drug-drug interactions. Chem. Res. Toxicol. 9, 476-483.
5. Goodwin, D. C., Aust, S. D., and
Grover, T. A. 1996. Free radicals produced during oxidation
of hydrazines by hypochlorous acid.
Chem. Res. Toxicol. 9, 1333-1339.
4. Goodwin, D. C., Aust, S. D., and
Grover, T. A. 1995. Evidence
for veratryl alcohol as a redox mediator in lignin peroxidase-catalyzed
oxidation. Biochemistry 34, 5060-5065.
3. Goodwin, D. C., Yamazaki, I., Aust, S.
D., and Grover, T. A. 1995. Determination of transient-state rate constants
for rapid peroxidase reactions. Analyt.
Biochem. 231, 333-338.
2. Goodwin, D.C., Barr, D. P., Aust, S.
D., and Grover, T. A. 1994. The role of oxalate in lignin
peroxidase catalyzed reduction: Protection from compound III accumulation. Arch. Biochem. Biophys. 315: 267-272.
1. Goodwin, D.C., and Lee, S. B. 1993. Rapid, microwave mini-prep of total genomic DNA from fungi,
plants, protists and animals for PCR.
Biotechniques 15: 438- 444.
Cook, C.O., Moore, R.L., and Goodwin, D. C. 2008. Role of R117 and D597 interdomain
residues in the reactivation of E. coli catalase-peroxidase. American Chemical Society, 235th
National Meeting, New Orleans, LA.
Cook, C.O., and Goodwin, D.C. 2008. Role of
the central hydrogen bonding network interdomain residues in the bifunctionality
of catalase-peroxidases. NOBCChE
35th Annual Conference, Philadelphia, PA.
Cook, C.O., Moore, R.L., Goodwin, D.C. 2007. Effect of
Distant, Intradomain Residues on Restoring the Catalase-Peroxidase Bifunctional
Active Site, Southeast Regional Meeting of the American Chemical Society, Greenville, SC.
Moore, R.L., Williams,
R., and Goodwin, D.C. 2007. Role
of interdomain interaction of tyrosine 111 on catalase-peroxidase , Southeast
Regional Meeting of the American Chemical Society, Greenville, SC.
Whitley, E.M., Goodwin, D.C., Cupp, M.S., Todd, L.W., Zhang, D., Mount, J.D., Powell, L.J., and Cupp, E.W. 2007. Conformational and functional stability and immunogenicity of a vasoactive insect salivary protein, Experimental Biology Annual Meeting, Washington, DC.
Varnado, C.L., Olson, J.S., and Goodwin D.C. 2007. Expression of recombinant hemoproteins in E. coli using a heme protein expression system, 51st Annual Meeting of the Biophysical Society, Baltimore, MD.
Goodwin, D.C., Cook, C.O., Moore, R.L. 2007. Roles of distant but highly conserved interactions in maintaining active site function in catalase-peroxidases. Gordon Conference: Enzymes, Coenzymes, and Metabolic Pathways, Biddeford, ME.
Cook, C. O., Moore, R. L., Goodwin, D. C. 2007. Role of intrasubunit interactions between domains in catalase-peroxidase structure and activity. American Chemical Society, 233rd National Meeting, Boston, MA.
Department of
Chemistry, Jacksonville State University, February 20, 2007. ³Structures and Mechanisms of
Hemoproteins: Implications for
Enzyme Engineering, Bacterial Virulence, and Antibiotic Resistance².
Goodwin, D. C., Cook, C. O., Baker, R. D. 2006. Modulation of catalase-peroxidase active site structure and catalysis by distant protein structures. American Chemical Society, 231st National Meeting, Atlanta, Georgia.
Moore, R., Goodwin, D. C., Laband, K. A., and Powell, L. 2006. Role of interdomain salt bridge on catalase-peroxidase activity. American Chemical Society, 231st National Meeting, Atlanta, Georgia.
Cook, C. O., Baker, R., and Goodwin, D. C. 2006. Function of a gene-duplicated domain in catalase-peroxidase structure and activity. American Chemical Society, 231st National Meeting, Atlanta, Georgia.
Department of Chemistry and Physics, Georgia College and State University, Milledgeville, GA, February 2006. Contribution of Protein Structural Features to the Unique Catalytic Properties of Catalase-Peroxidases: Implications for Bacterial Virulence, Antibiotic Resistance, and Enzyme Engineering.
Department of Chemistry, University of West Florida, Pensacola, FL, October 21, 2005. Contribution of Protein Structural Features to the Unique Catalytic Properties of Catalase-Peroxidases: Implications for Bacterial Virulence, Antibiotic Resistance, and Enzyme Engineering.
Li, Y., and Goodwin D. C. 2004. Central participation of an interhelical insertion in catalase-peroxidase bifunctionality and resistance to peroxide-dependent inactivation. Southeast Regional Meeting of the American Chemical Society, Research Triangle Park, North Carolina.
Baker, R. D., Cook, C. O., and Goodwin D. C. 2004. Essential contribution of the C-terminal domain to the structure of the catalase-peroxidase active site. Southeast Regional Meeting of the American Chemical Society, Research Triangle Park, North Carolina.
Cook, C. O., Baker, R. D., and Goodwin, D. C. 2004. Catalase-peroxidase active site restructuring by a distant and inactive domain. Southeast Regional Meeting of the American Chemical Society, Research Triangle Park, North Carolina.
Laband, K. A., Baker, R. D., and Goodwin, D. C. 2004. Contributions of an interdomain ion pair to the bifunctional properties of catalase-peroxidases. Southeast Regional Meeting of the American Chemical Society, Research Triangle Park, North Carolina.
Varnado, C. L., and Goodwin D. C. 2004. Heme- and
peroxide-dependent formation of a novel crosslink in catalase-peroxidases. Southeast Regional Meeting of the
American Chemical Society, Research
Triangle Park, North Carolina.
Department of Chemistry and Biochemistry, University of
Delaware, Newark, DE, November 1, 2004. Protein Structural Contributions
to the Unique Catalytic Properties of Catalase-Peroxidases.
Department of Biochemistry, Wake Forest University,
Winston-Salem, NC, August 3, 2004.
Protein Structural Contributions to the Unique Catalytic Properties
of Catalase-Peroxidases.
Goodwin, D. C., Baker, R. D., Cook, C. O., and Laband, K. A.
2004. Integral Involvement of an Inactive
Domain in Catalase-Peroxidase Structure and Catalysis Gordon Conference:
Enzymes, Coenzymes, and Metabolic Pathways, Meriden, NH, July 20.
Department of Chemistry, New York University, New York, NY,
April 26, 2004. Protein Structural Contributions to the Unique Catalytic
Properties of Catalase-Peroxidases.
Department of Biochemistry, Vanderbilt University,
Nashville, TN, March 26, 2004. Structural Requirements for the
Hemoprotein-Dependent Decomposition of Hydroperoxides: Lessons from the Catalase-Peroxidases.
Department of Chemistry and Physics, LaGrange College,
LaGrange, GA. March 10, 2004. Hemoprotein Structure and
Mechanism: Implications for Enzyme Engineering, Bacterial Virulence, and Antibiotic
Resistance.
Department of Chemistry, Butler University, Indianapolis,
IN. February 18, 2004. Structural Requirements for the
Hemoprotein-Dependent Decomposition of Hydroperoxides: Lessons from the Catalase-Peroxidases.
Department of Chemistry, Case Western Reserve University,
Cleveland, OH. February 6,
2004. Structural Requirements for
the Hemoprotein-Dependent Decomposition of Hydroperoxides: Lessons from the Catalase-Peroxidases.
Department of Chemistry and Physics, Georgia College and State University, Milledgeville, GA. February 2, 2004. Hemoprotein Structure and Mechanism: Implications for Enzyme Engineering, Bacterial Virulence, and Antibiotic Resistance.
Goodwin, D. C., Baker, R. D., Varnado, C. L., and Li,
Y. 2003. Structural Requirements for the Hemoprotein-Dependent
Decomposition of Hydroperoxides:
Lessons from the Catalase-Peroxidases. Symposium Title: Chemistry and Biology of Oxidative
Damage. Southeast Regional Meeting
of the American Chemical Society, Atlanta,
GA.
Varnado, C. L., and Goodwin, D. C. 2003. Characterization of a Novel Periplasmic
Catalase-Peroxidase. Southeast Regional Meeting of the American Chemical
Society, Atlanta, Georgia.
Baker, R., and Goodwin D. C. 2003. Insight into the Role of
the C-Terminal Domain in Catalase-Peroxidase Function. Southeast Regional Meeting of the
American Chemical Society, Atlanta,
Georgia.
Laband, K. A., and Goodwin D. C. 2003. Peroxidase-Catalyzed
Oxidation of Plant-Derived o-Methoxyphenols: Implications for the Metabolism of Health-Promoting
Phenolic Compounds. Southeast
Regional Meeting of the American Chemical Society, Atlanta, Georgia.
Li, Y., and Goodwin D. C. 2003. Use of Deletion Mutagenesis
to Determine the Novel Functions of Two Unique Interhelical Insertions in
Catalase-Peroxidases. Southeast
Regional Meeting of the American Chemical Society, Atlanta, Georgia.
Baker, R., and Goodwin, D. C. 2003. Essential Role of the C-terminal Domain in
Catalase-Peroxidase Function. American
Chemical Society, 226th National Meeting, New York, NY.
Sept 9, 2003; Bioinorganic Chemistry.
Li, Y., and Goodwin, D. C. 2003. Roles of Two
Interhelical Insertions in Catalase-Peroxidase Bifunctionality. American Chemical Society, 226th
National Meeting, New York, NY. Sept 9, 2003; Bioinorganic Chemistry.
Varnado, C. L., Hertwig, K. M., Thomas, R., Roberts, J.
K., and Goodwin, D. C. 2003. Spectral and Kinetic Properties of a Novel
Periplasmic Catalase-Peroxidase. American
Chemical Society, 226th National Meeting, New York, NY.
Sept 10, 2003; Biological Chemistry
Goodwin, D. C., Baker, R., Varnado, C. L., and Li, Y. 2003. Protein Structural Contributions
to the Unique Catalytic Properties of Catalase-Peroxidases. Gordon Conference: Enzymes,
Coenzymes, and Metabolic Pathways,
Meriden, NH, July 14-17, 2003.
Goodwin D. C. Hemoprotein Structure and Mechanism: Implications for Enzyme Engineering, Bacterial Virulence, and Antibiotic Resistance. Department of Chemistry, State University of West Georgia, Carrollton, GA. April 11, 2003.
Varnado, C. L., and Goodwin, D. C. 2002. Design of a specialized expression
system for recombinant hemoproteins. Southeast Regional Meeting of the
American Chemical Society, Charleston,
South Carolina, November 14, 2002.
Baker, R., Li, Y., and Goodwin D. 2002. Selective Elimination
of Catalase Activity from Catalase-Peroxidase by Deletion Mutagenesis. Southeast Regional Meeting of the
American Chemical Society, Charleston,
South Carolina, November 15, 2002.
Goodwin, D. C. Hemoprotein Structure and Mechanism: Implications for Enzyme Engineering, Bacterial Virulence, and Antibiotic Resistance. Department of Chemistry, University of Mississippi, Oxford, MS. October 18, 2002.
Goodwin, D. C., Li, Y., and Baker, R. 2002. Selective Elimination of Catalase Activity from Catalase-Peroxidase
by Deletion Mutagenesis. Gordon
Conference: Enzymes, Coenzymes, and Metabolic Pathways, Meriden, NH, July 23 and 24, 2002.
Hertwig, K. M., and Goodwin, D. C. 2002. Characterization of a novel,
extracellular catalase-peroxidase from E. coli O157:H7. Council
on Undergraduate Research, Posters on the Hill Forum, Washington, D.C.
April 18, 2002.
Hertwig, K. M. and Goodwin, D. C. 2001. Cloning, overexpression, purification,
and characterization of catalase/peroxidase from enterohemorrhagic E. coli O157:H7. Amer.
Chem. Soc. Southeast Regional Meeting,
Savannah, GA.
Li, Y., Melius, P., and Goodwin, D. C. 2001. Activation of
Bacterial Catalase-Peroxidases by Addition of Hemin. Amer. Chem. Soc., Southeast Regional Meeting, Savannah, GA.
Hertwig, K. and Goodwin, D. C. 2001. Cloning, overexpression, purification,
and characterization of catalase/peroxidase from enterohemorrhagic E. coli O157:H7. Amer. Chem. Soc. 222nd National Meeting, Chicago, IL.
Goodwin, D. C. Catalase/Peroxidase Structure, Function, and Kinetics: Implications for Antibiotic Resistance and Bacterial Virulence. Department of Chemistry, State University of West Georgia, Carollton, GA. April 27, 2000.
Goodwin, D. C. Mechanisms of Prostaglandin Biosynthesis: Generation and Trapping of Tyrosyl Radicals. Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX. April 26, 1999.
Goodwin, D. C.
Structure and Function of Catalase/Peroxidases: Implications for Antibiotic Resistance and
Virulence. Department of Chemistry and Biochemistry, University of Texas at
Arlington, Arlington, TX. April
27, 1999.
Goodwin D. C. Mechanisms of Prostaglandin Biosynthesis: Generation and Trapping of Tyrosyl Radicals. Department of Chemistry, Auburn University, Auburn, AL. January 29, 1999.
Goodwin, D. C.
Structure and Function of Catalase/Peroxidases: Implications for Antibiotic Resistance
and Virulence. Department of Chemistry, Auburn University, Auburn, AL. April 26, 1999.
Goodwin, D.C., Rowlinson, S. W., and Marnett, L. J.
1998. Heme oxidation states in
prostaglandin endoperoxide H synthase catalytic mechanism. Amer. Chem. Soc.
216th National Meeting, Boston, MA.
Rowlinson, S.W., Crews, B. C., Goodwin D. C., and Marnett
L. J. 1998. Structure/function analysis on the cyclooxygenase channel of mouse
prostaglandin endoperoxide synthase-2. Amer. Chem. Soc. 216th National
Meeting, Boston, MA.
Goodwin, D.C., Gunther, M. R., Hsi, L. C., Crews, B. C., Eling,
T. E., Mason, R. P., and Marnett, L. J. 1997. Nitric oxide trapping of the Y385
radical during prostaglandin endoperoxide synthase turnover. Intl. Congress
Biochemistry Mol. Biol./Amer. Soc. Biochemistry Mol. Biol. Joint Meeting, San Francisco, CA.
Goodwin, D. C. Kinetics of redox mediation in peroxidase catalysis: implications for metabolism of xenobiotics. Department of Biochemistry, Center in Molecular Toxicology, School of Medicine, Vanderbilt University, Nashville, TN. April 2, 1996.
Goodwin, D. C. Kinetics of redox mediation in peroxidase catalysis: implications for metabolism of xenobiotics. Atherosclerosis, Nutrition, and Lipid Research Division, School of Medicine, Washington University, Saint Louis, MO, April 4, 1996.
Goodwin, D.
C. Kinetics of redox mediation in
peroxidase catalysis: implications
for metabolism of xenobiotics.
Department of Biochemistry, Michigan State University, East Lansing, MI,
April 8, 1996.
Goodwin, D.C., Aust, S. D., and Grover, T. A. 1996. Enhancement of peroxidase-catalyzed oxidation of hydrazine
derivatives by chlorpromazine. Amer. Soc. Biochemistry Mol. Biol. National
Meeting, New Orleans, LA.
Goodwin, D.C., Aust, S. D., and Grover, T. A. 1996. Enhancement of peroxidase-catalyzed xenobiotic oxidation by
phenothiazines. Soc. Toxicol. Annual Meeting, Anahiem, CA.
Goodwin, D.C., Aust, S. D., and Grover, T. A. 1995. Phenothiazines as redox mediators in peroxidase-catalyzed
xenobiotic oxidation. Soc. Toxicol. Mountain West Chapter Annual Meeting, Ft. Collins, CO.
Goodwin, D. C., Yamazaki, I., Aust, S. D., and Grover, T.
A. 1995. Determination of transient-state rate constants for
peroxidase reactions. Amer. Soc. Biochemistry Mol. Biol./Amer. Chem. Soc.
Div. Biol. Chem. National Meeting, San Francisco,
CA.
Goodwin, D.C., Aust, S. D., and Grover, T. A. 1995. Redox mediators in lignin peroxidase catalysis: A kinetic
model. Amer. Soc. Biochemistry Mol. Biol./Amer. Chem. Soc. Div. Biol. Chem.
National Meeting, San Francisco, CA.
Grover, T.A., Goodwin, D. C., Barr, D. P., and S.D.
Aust. 1994. Protection of lignin peroxidase
activity: oxalate and cation radicals. Intl. Soc. Free Rad. Res. 7th
Biennial Meeting, Sydney, Australia.
Goodwin, D.C., Aust, S. D., and Grover, T. A. 1994. Veratryl alcohol (VA) mediated oxidation by lignin
peroxidase. Intl. Soc. Free Rad. Res. 7th Biennial Meeting, Sydney, Australia.
Goodwin, D.C., Barr, D. P., Aust, S. D., and Grover, T.
A. 1994. Inactivation of lignin peroxidase of Phanerochaete chrysosporium
by oxygen radicals. Amer. Soc. for
Microbiol. 94th General Meeting, Las
Vegas, NV.
Goodwin, D. C., Barr, D. P., Aust, S. D., and Grover, T.
A. 1994. The novel role of the fungal metabolite oxalate in the
catalytic cycle of lignin peroxidase. Amer. Soc. Microbiol. Intermountain Branch Annual Meeting, Provo, UT.
Goodwin, D. C., Johnston, C. G., Aust, S. D., and Grover,
T. A. 1993. Microwave extraction of DNA from fungi
in soil: a simple, rapid method for polymerase chain reaction. Amer. Soc. Microbiol.,
93rd General Meeting, Atlanta, GA.
Johnston, C.G., Goodwin, D. C., and Aust, S. D. 1994. Use
of ribosomal DNA for species delineation and detection of Phanerochaete spp.
Amer. Soc. Microbiol. 94th General Meeting,
Las Vegas, NV.
Goodwin, D.C., and Lee, S. B. 1992. Ribosomal DNA sequences
of Leptomitus lacteus, Sapromyces
elongatus, Aquilinderella fermentans, and Rhipidium sp.
and their evolutionary
implications for the Oomycete order Leptomitales. Soc. Study Evol., University of California, Berkeley, CA.
National Science Foundation (MCB-0641614)
PI: Goodwin, D. C.
Dates: 7/1/07 – 6/30/10
Indispensable Roles of an Inactive Domain in Catalase-Peroxidase Catalysis: Applications for Enzyme Engineering
United
States Department of Agriculture, Hatch Grant and Alabama Agricultural
Experiment Station Special Grants Program.
PD: Elizabeth Whitley. Co-PDs: Dwight Wolfe, M Edmonson, Douglas C. Goodwin, , Development of Vaccines Targeting Horn Flies
USDA CSREES Special Research Grants
PI: Wolfe, D. Co-PI¹s: Goodwin, D. C., Whitley, E., and Abrams, M.
Dates: 8/1/06 – 7/31/07)
Evaluation of a Horn Fly Polyvalent Vaccine for Cattle
A protective vaccine for cattle against horn flies is being developed. The antigens are derived from salivary proteins produced by this insect. The Goodwin group is using CD and other techniques to evaluate structure and stability of the component proteins and gain insight into the function of these proteins in blood feeding.
Role: Co-PI
PRISM 2004
PI: Goodwin, D. C. Co-PI¹s: Ellis, H. R., Duin, E. C., Striegler, S., and Singh, N.
Dates: 4/1/04 – 3/31/05
Circular Dichroism at Auburn University
Funds were requested for the purchase of a circular dichroism spectropolarimeter with Peltier temperature control system and autotitration system.
Role: Principal Investigator
PRF
# 38802 – G4 PI: Goodwin, D. C. Dates: 1/1/2003 –
9/30/2005
Understanding the Bifunctional Active Site of
Catalase-Peroxidases: Insights for Enzyme Engineering.
In these studies, deletion mutagenesis is used to identify
the role of catalase-peroxidase-unique structural components in the
bifunctional catalytic abilities of catalase-peroxidases.
Role: Principal Investigator
Biogrant 2-1319200 PI: Goodwin, D. C. Dates 5/1/2001 –
4/30/2003
Alabama Biogrant through Auburn University
Mechanisms of Heme Acquisition by Enterohemorrhagic E.
coli strain O157:H7.
In these studies, investigators seek to evaluate the
influence of perturbations in heme structure on heme binding by a receptor
isolated from enterohemorrhagic E. coli.
Role:
Principal Investigator
Current:
Carma O. Cook, Ph.D. Candidate, Chemistry, Project:
Reactivation of the catalase-peroxidase N-terminal domain.
Shalley Kudalkar, Ph.D. Student, Chemistry, Project:
Catalase-peroxidase N-terminal domain structural analysis.
Robert Moore, Ph.D. Candidate, Chemistry, Project:
Interdomain interactions in catalase-peroxidases and their impact on active
site function.
Yu Wang, Ph.D Student, Chemistry, Project: Function of
the catalase-peroxidase C-terminal domain.
Previous:
Ruletha Baker, Ph.D. Graduate, Chemistry, Dissertation
Title: Roles of an inactive domain
in in catalase-peroxidase catalysis: Modulation of active site architecture and
function by gene duplication. Defense date: August 14, 2006.
Cornelius Varnado, Ph.D. Graduatea, Chemistry,
Dissertation Title: Enhancing
expression of recombinant hemoproteins: Progress toward understanding
structure/function and therapeutic application. Defense date: June 29,
2006.
Ronald Marcy, GND Graduate Student, Chemistry,
Project: Structure and function of
catalase-peroxidases. Progress: Ron is an instructor at Alabama Southern Community College
who worked in the laboratory to get exposure to the latest techniques in
biochemistry and molecular biology in order to enhance teaching of his chemistry
and microbiology courses.
Chengdong Huang, Ph.D. Student, Chemistry, Major
Professor: Dr. Smita Mohanty
Russell Carpenter, Ph.D. Candidate, Chemistry, Major Professor:
Dr. Holly Ellis
Erin Imsand, Ph.D. Student, Chemistry, Major Professor:
Dr. Holly Ellis
Weiya Xu, Ph.D. Candidate, Chemistry, Major Professor:
Dr. Evert Duin
Sidharth Venkatesh, Ph.D. Candidate, Chemical
Engineering, Major Professor: Dr. Mark Byrne
Weikuan Li, Ph.D. Candidate, Chemistry, Major Professor:
Dr. Stewart Schneller
Trafina Jadhav, Ph.D. Student, Biological Sciences,
Major Professor: Dr. Marie Wooten
Matthew Goodwin, Ph.D. Student, Health and Human
Performance, Major Professor: Dr. Bruce Gladden
James Harris, Ph.D. Candidate, Health and Human
Performance, Major Professor: Dr. Bruce Gladden
Jody Burks, Ph.D. Student, Animal Science, Major
Professor: Dr. Jacek Wower
Mi Wang, Ph.D. Candidate, Chemistry, Major
Professor: Dr. Evert Duin
Xuanzhi Zhan, Ph.D. Graduate, Chemistry, Major
Professor: Dr. Holly Ellis
Rajesh Gupta, Ph.D. Graduate, Chemical Engineering, Major
Professor: Dr. Yoon Lee
John-Ryan McAnnally, M.S. Graduate, Biological Sciences,
Major Professor: Dr. James Bradley
Kholis Abdurachim, Ph.D. Graduate, Chemistry Major
Professor: Dr. Holly Ellis
Dolapo Adedji,
Ph.D. Graduate, Chemistry, Major Professor: Dr. Evert Duin
Na Yang, Ph.D. Graduate, Chemistry, Major Professor: Dr. Evert Duin
Honglei Sun, M.S. Graduate, Chemistry, Major
Professor: Dr. Holly Ellis
Benlian Gao, Ph.D. Graduate, Chemistry, Major
Professor: Dr. Holly Ellis
Ling Tang, Ph.D. Graduate, Animal Science, Major
Professor: Dr. Werner Bergen
Rong Wu, Ph.D. Graduate, Chemistry, Major Professor: Dr. S. D. Worley
Wei Ye, Ph.D. Graduate, Chemistry, Major Professor: Dr. Stuart Schneller
Darcy Goodwin, Masters Graduate, Animal and Dairy Sciences, Major Professor: Dr. Skip Bartol
Amanda Bean, Ph.D. Graduate, Chemistry, Major
Professor: Dr. Thomas
Albrecht-Schmitt
Ben Stronach, Masters Graduate, Animal and Dairy Sciences,
Major Professor: Dr. Werner Bergen
Wendy White, Masters Graduate, Biological Sciences, Major
Professor: Dr. Marie Wooten
Chunru Lin, Ph.D. Student (resigned), Biology, Major
Professor: Dr. Marie Wooten
BCHE
7220 Principles of Cellular and Molecular Enzymology
CHEM
640 Biochemistry
CHEM
7950 Biochemistry Seminar
CHEM 7930 Directed Individual Study
CHEM
7750 Formal Presentations in Chemistry
Robert Andrew Campbell, Undergraduate (Junior,
Biochemistry) Auburn University, May 2008 – present. Auburn University Cellular and
Molecular Biosciences Summer Research Fellow.
Michelle Muldowney, Undergraduate (Junior, Biochemistry)
Auburn University, August 2007 - present
JaRyce Nabors, Undergraduate (Junior, Biochemistry) Auburn
University, August 2007 – May 2008.
Joey Russel, Undergraduate (Biomedical Sciences) Auburn
University, January 2008 – May 2008.
W. C. (Dub) Davison, High School Student (Senior, McAdory
High School) Auburn University Cellular and Molecular Biosciences Teaching
Enhancement Program, June 2006.
Jessica Williams, Undergraduate (Sophomore, Chemistry),
Auburn University, May 2007 – August 2007.
Michael Love, Undergraduate (Junior, Chemistry), Auburn
University, January 2007 – December 2007 (excluding summer months).
JaRyce Nabors, Undergraduate (Junior, Biochemistry) Auburn
University May 2006 – August 2006.
EPSCoR Undergraduate Summer Research Fellow.
Jennifer Smith, Undergraduate (Junior, Biochemistry),
Auburn University January 2006 – May 2006.
Allan Bagget, Undergraduatee (Senior, Biomedical Sciences),
Auburn University January 2006 – May 2006.
Grant Nelson, Undergraduate (Senior, Microbiology), Auburn
University; January 2007 – March 2007.
Rachel Williams, Undergraduate (Sophomore, Chemistry),
Auburn University; January 2007 – December 2007.
Justin Alex Taylor, Undergraduate (Junior, Chemistry),
Auburn University; August 2006 – December 2006.
Luke Powell, Undergraduate (Senior, Biomedical Sciences),
Auburn University; August 2005 – August 2006. COSAM Research Fellow
Kimberley Laband, Undergraduate (Junior, Molecular
Biology), Auburn University; May 2002 – May 2005.
Daniel Carter, Undergraduate (Senior, Biomedical Sciences),
Auburn University, August 2004 – December 2004.
Byron
Smith, Undergraduate (Senior, Biomedical Sciences), Auburn University, August
2004 – December 2004.
Stephen Pehler, Undergraduate (Junior, Molecular Biology), Auburn University; April 2004 – October 2004.
Tyson Kilpatrick, Undergraduate (Senior, Biomedical
Sciences), Auburn University; January 2004 – May 2004.
Greyson McGowin, Undergraduate (Senior, Biomedical
Sciences), Auburn University; May 2003 – September 2003. CMB
Research Fellow
Derek Fortson, Undergraduate (Senior, Biochemistry), Auburn University; August 2002 – May 2003.
Sarah Peaslee Undergraduate (Senior, Biochemistry), Auburn
University; June 2002 – May 2003.
Melanie Oliver, Undergraduate (Senior, Microbiology) Auburn
University; May 2002 – December 2002.
J. Kenneth Roberts, Undergraduate (Senior, Biomedical
Sciences), Auburn University; June 1, 2002 – May 10, 2003.
Robert Thomas, Undergraduate, Asbury College, Wilmore,
KY.; May 15, 2002 – August
15 2002.
Kristin Hertwig, Undergraduate (Graduated, Biochemistry),
Auburn University; January 15, 2000 – December 2002.
Erika
Schansberg, Undergraduate (Graduated, Microbiology), Auburn University; August
2001 – May 2002.
Thomas Cash, Undergraduate (Graduated, Chemistry), Auburn
University; January 2002 – May 2002.
Matthew McIntyre, Undergraduate (Graduated, Biomedical Sci.), Auburn University; May 2001 – August 2001.
Nancy Ruth Wilkins, Undergraduate (Graduated, Biochemistry), Auburn University; May 2001 – August 2001.
Emily Brantley, Undergraduate (Graduated, Molecular
Biology), Auburn University; June 2000 – December 2001.
Juan Carmona, Undergraduate (Graduated, Molecular Biology),
Auburn University; August 2000 – May 2001.
Amy Wainwright, Undergraduate (Graduated, Biochemistry),
Auburn University; January 4, 2000 – June 6, 2000.
Randy Booth, Undergraduate (Graduated, Biochemistry) Utah
State University; May 20, 1996 – August 20, 1996.
Joseph Benson, Undergraduate (Graduated, Biochemistry) Utah
State University; May 20, 1995 - May 20, 1996.
Curtis Takemoto, Undergraduate (Graduated, Political Science) Utah State University; May 20, 1994 – May 20, 1996.
L. Undergraduate Courses Taught (*Graduate
Students Enrolled From Other Depts.)
*BCHE 5180/6180 General Biochemistry I
*BCHE 5190/6190 General Biochemistry II
BIOL
4980 Undergraduate Research
CHEM
4901 Special Problems in Chemistry
CHEM
4950 Undergraduate Seminar
CHEM
1030 Fundamentals of Chemistry I
CHEM
1020 Survey of Chemistry II
SCMH
1010 Concepts of Science