L. Bruce Gladden

Professor

Ph.D:University of Tennessee, Knoxville (1976)
Dissertation:Efficiency of anaerobic work.

Graduate Classes:

Research Program:

Oxygen uptake on-kinetics

Grassi, Bruno, Michael C. Hogan, Kevin M. Kelley, William G. Aschenbach, Jason J. Hamann, Ronald K. Evans, Robin E. Pattillo, and L. Bruce Gladden. Role of convective O₂ delivery in determining VO₂ on-kinetics in canine muscle contracting at peak VO₂. Journal of Applied Physiology 89: 1293-1301, 2000
Grassi, Bruno, L. Bruce Gladden, Creed M. Stary, Peter D. Wagner, and Michael C. Hogan. Peripheral O₂ diffusion does not affect VO₂ on-kinetics in isolated in situ canine muscle. Journal of Applied Physiology 85: 1404-1412, 1998
Grassi, Bruno, L. Bruce Gladden, Michele Samaja, Creed M. Stary, and Michael C. Hogan. Faster adjustment of O₂ delivery does not affect VO₂ on-kinetics in isolated in situ canine muscle. Journal of Applied Physiology 85: 1394-1403, 1998

Exercise metabolism/biochemistry of exercise/fatigue

Samaja, Michele, Sonia Allibardi, Giuseppina Milano, Gabriella Neri, Bruno Grassi, L. Bruce Gladden, and Michael C. Hogan. Differential depression of myocardial function and metabolism by lactate and H⁺. American Journal of Physiology: Heart and Circulatory Physiology 276: H3-H8, 1999
Hogan, Michael. C., L. Bruce Gladden, Bruno Grassi, Creed M. Stary, and Michele Samaja. Bioenergetics of contracting skeletal muscle after partial reduction of blood flow. Journal of Applied Physiology 84: 1882-1888, 1998
Portington, Kevin J., David D. Pascoe, Michael J. Webster, Layne H. Anderson, Rodney R. Rutland, and L. Bruce Gladden. Effect of induced alkalosis on exhaustive leg press performance. Medicine and Science in Sports and Exercise 30: 523-528, 1998
Pascoe, David D. and L. Bruce Gladden. Glycogen resynthesis follwing short term high intensity exercise and resistance exercise. Sports Medicine 21:98-118, 1996
Hogan, Michael C., L. Bruce Gladden, Sadi Kurdak, and David C. Poole. L-(+)-lactate infusion into submaximally working dog gastrocnemius: increased muscle [lactate] reduces tension development independent of pH. Medicine and Science in Sports and Exercise 27: 371-377, 1995

Lactic acid metabolism

Gladden, L. Bruce. Lactic acid: New roles in a new millenium. Proceedings of the National Academy of Science 98: 395-397, 2001
Gladden, L. Bruce. Muscle as a consumer of lactate. Medicine and Science in Sports and Exercise 32: 764-771, 2000.
Hogan, Michael. C., L. Bruce Gladden, Sadi Kurdak, and David C. Poole. L-(+)- lactate infusion into submaximally working dog gastrocnemius: increased muscle [lactate] reduces tension development independent of pH. Medicine and Science in Sports and Exercise 27:371-377, 1995
L. Bruce Gladden, Robert E. Crawford, and Michael J. Webster. Effect of lactate concentration and metabolic rate on net lactate uptake by canine skeletal muscle. American Journal of Physiology: Regulatory Integrative and Comparative Physiology 35:R1095-R1101, 1994.
Poole, David C., L. Bruce Gladden, Sadi Kurdak, and Michael C. Hogan. L-(+)- Lactate infusion into working dog gastrocnemius. No evidence that lactate per se mediates VO₂ component. Journal of Applied Physiology 76:787-792, 1994.
L. Bruce Gladden, Robert E. Crawford, and Michael J. Webster. Effect of blood flow on net lactate uptake during steady-state contractions in canine skeletal muscle. Journal of Applied Physiology 72(5):1826-1830, 1992.
L. Bruce Gladden. Net lactate uptake during progressive steady-level contraction in caninne skeletal muscle. Journal of Applied Physiology 71(2):514-520, 1991.

Tissue exchange of lactic acid

Smith, Edith W., Michele S. Skelton, DuAnn E. Kremer, David D. Pascoe, and L. Bruce Gladden. Lactate distribution in the blood during steady-state exercise. Medicine and Science in Sports and Exercise 30: 1424-1429, 1998
Smith, Edith W., Michele S. Skelton, DuAnn E. Kremer, David D. Pascoe, and L. Bruce Gladden. Lactate distribution in the blood during progressive exercise. Medicine and Science in Sports and Exercise 29:654-660, 1997
L. Bruce Gladden. Lactate transport and metabolism during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple systems, edited by Loring B. Rowell and John T. Shepherd. New York: Oxford University Press, 1996, pp. 614-648.

Lactic acid transport across skeletal muscle membrane

Aschenbach, William G., Gregory L. Brower, Robert J. Talmadge, John L. Dobson, and L. Bruce Gladden. Effect of a myocardial overload on lactate transport in skeletal muscle sarcolemmal vesicles. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 281: R176-R186, 2001.
L. Bruce Gladden, Robert E. Crawford, Michael J. Webster, and Peter W. Watt. Rapid tracer lactate influx into canine skeletal muscle. Journal of Applied Physiology 78:205-211, 1995
Watt, Peter W., L. Bruce Gladden, Harinder S. Hundal, and Robert E. Crawford. Effects of flow and contraction on lactate transport in the perfused rat hindlimb. American Journal of Physiology: Endocrinology and Metabolism 267:E7-E13, 1994

Lactic acid transport by red blood cells.

Skelton, Michele S., DuAnn E. Kremer, Edith W. Smith, and L. Bruce Gladden. Lactate influx into red blood cells from trained and untrained human subjects. Medicine and Science in Sports and Exercise 30:536-542, 1998
Skelton, Michele S., DuAnn E. Kremer, Edith W. Smith, and L. Bruce Gladden. Lactate influx into red blood cells of 'athletic' and 'non-athletic' species. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 268:R1121-R1128, 1995

For additional information gladdlb@.auburn.edu