I.   Introduction & Class Procedures (See Handout)

  II.  Course Objectives

III. The fluid compartments
 

        A.     Intracellular
        B.     Extracellular
                 1.Major Categories
                    a. Interstitial
                    b. Plasma
                 2.Minor Categories
                    a. Lymph
                    b. Transcellular
                    c.  Boundaries & Measurement

 IV. The Cell Membrane - Fluid Mosaic Model
       A.       Lipid Component
                  1. Descriptions
                  2. Functions
       B.       Protein Component
                  1. Types
                  2. Functions
       C.       Transfer of Information
                  1. Alteration of membrane ionic permeabilities
                  2. Cyclic AMP
                  3. Calcium & Phosphoinositides
                  4. Steroids
         D.   Transfer of Materials
                  1. Passive Transport Mechanisms
                       a. Simple Diffusion
                                 - through membrane
                                 - through pores
                       b. Carrier Facilitated Diffusion
                       c. Osmosis
                  2. Cellular Energy Dependent Transport Processes
                        a. Primary (Direct)
                        b. Secondary Active
                        c. Bulk Transport

  V. Pathologies
        A.    G-Proteins
                  1. Pituitary giantism and acromegaly
                  2. Vibrio cholerae
        B.     Chloride channels - cystic fibrosis