Harrison School of Pharmacy

Faculty and Staff Directory

 

Dmitriy Minond Dmitriy Minond
Associate Professor

Department: Drug Discovery and Development
Auburn University
Harrison School of Pharmacy
4306 Walker Building
Auburn, AL 36849
Email: dzm0032@auburn.edu
Phone: 334-844-7409
Fax: 334-844-8331
 Bio

Education:
M.S., Biology and Biochemistry - Odessa State University (Ukraine), 1993
Ph.D., Chemistry and Biochemistry - Florida Atlantic, 2006

Areas of Interest:

  • Drug Discovery
  • Enzymology
  • Chemical Biology
  • Lab Automation and Robotics

Dmitriy Minond joined the Harrison School of Pharmacy on Aug. 1, 2015 as an associate professor in the Department of Drug Discovery and Development, focusing on Pharmaceutical Engineering.

Minond earned a master’s degree in biology and biochemistry from Odessa State University in Odessa, Ukraine in 1993. He later earned his Ph.D. in chemistry and biochemistry from Florida Atlantic University in 2006. Minond went on to complete a fellowship as a Post-Doctoral Scientific Associate at The Scripps Research Institute in Jupiter, Florida from 2006-09.

From 2009-10, Minond held the position of Senior Scientist - High Throughput Screening Lead ID Department with the Translational Research Institute in Scripps Florida. He then joined the Torrey Pines Institute for Molecular Studies in Port St. Lucie, Florida as Assistant Member/Principal Investigator, a position he held until arriving at Auburn.

 Research Interests

The common goal of projects in Dr. Minond's laboratory is to achieve understanding of basic mechanisms of biochemical regulation of activity of ADAM cell surface metalloproteases and, subsequently, their roles in diseases and normal biology. This understanding will potentially lead to validation of specific members of ADAM family as therapeutic targets and to the development of molecular tools to modulate their activity in diseases.

Dr. Minond's lab is also working on chemical biology methodologies for phenotypic screening to discover “first-in-class” molecules targeting drug-resistant cancers, including melanoma and lung cancer. In the lab's 2014 J Med Chem publication we described a mixture-based combinatorial libraries approach combined with parallel screening of multiple cell lines. This approach can potentially offer a cost- and time-effective solution to the discovery of chemical probes and drug candidates for cancer and other diseases.

In the lab's work, robotics are utilized to screen small compound drug discovery library and biochemical/cell-based approaches to characterize mechanism of action of lead molecules.

Potential areas of collaborations include, but are not limited to development of analytical methods and devices for drug discovery (e.g. microfluidics, array technologies), assay development and screening for novel compounds against targets of interest.

 Selected Publications (out of 35 total)
  • Dmitriy Minond. Metzincin Modulators: Beyond the Active Site. In “Matrix Metalloproteinase Biology”, 1st edition. Edited by Jean Gaffney and Irit Sagi. Wiley-Blackwell; 1st edition (May 27, 2015).
  • Anna Knapinska, Daniela Dreymuller, Lyndsay Smith, Vladislav Golubkov, Rafael Fridman, Marc Giulianotti, Richard A. Houghten, Gregg B. Fields and Dmitriy Minond. SAR Studies and Characterization of Exosite Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) as In Vitro Biological Probes. J Med Chem. 2015 Aug 13; 58(15):5808-24. PMID: 26192023
  • Nagalakshmi Jeedimalla, Madison Flint, Lyndsay Smith, Alberto Haces, Dmitriy Minond# and Stéphane P. Roche#. Multicomponent Assembly of 4-Aza-podophyllotoxins: A Fast Entry to Highly Selective and Potent Anti-Leukemic Agents. Accepted to Euro J Med Chem. # - indicates co-authorship
  • Timothy P. Spicer, Jianwen Jiang, Alexander B. Taylor, Jun Yong Choi, P. John Hart, William R. Roush, Gregg B. Fields, Peter S. Hodder, and Dmitriy Minond. Characterization of Selective Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation In Vitro. J Med Chem. 2014 Nov 26; 57(22):9598-611. PMID:25330343

Last Updated: February 23, 2017