Harrison School of Pharmacy

Faculty and Staff Directory

 

Amal Kaddoumi Amal Kaddoumi
Professor

Department: Drug Discovery and Development
Auburn University
Harrison School of Pharmacy
365 Pharmaceutical Research Building
720 South Donahue Drive
Auburn, AL 36849
Email: kaddoumi@auburn.edu
Phone: 334-844-7239
 Bio

Education:
B.Sc., Biochemistry - Kuwait University, 1985
M.S., Pharmaceutical Sciences - Nagasaki University (Japan), 2001
Ph.D., Pharmaceutical Sciences - Nagasaki University (Japan), 2004

Amal Kaddoumi, Ph.D. is a Professor in the Department of Drug Discovery and Development at the Harrison School of Pharmacy. She received her B.Sc. in Biochemistry from Kuwait University in 1985 and her M.S. in Pharmaceutical Sciences from Nagasaki University in 2001. Kaddoumi went on to complete her Ph.D. in Pharmaceutical Sciences from Nagasaki University in 2004.

Upon graduation, Kaddoumi took a positions as a postdoctoral research associate at the University of Michigan College of Pharmacy (2004-05) and the University of Washington School of Pharmacy (2005-06). In 2007, she joined the faculty at the University of Louisiana at Monroe School of Pharmacy, serving as an assistant professor from 2007-13 and an associate professor from 2013-17 in the Department of Basic Pharmaceutical Sciences.

Kaddoumi is an active member of the American Association of Pharmaceutical Scientists (AAPS), Alzheimer’s Association (Grants Peer Review Member), Society of Neuroscience, and the Oleocanthal International Society (OIS).

 Research Statement

My lab has extensive experience in drug development, preclinical research and bioanalysis in the fields of biopharmaceutics, neuropharmacology and brain research. The goal of my lab research is to enhance our knowledge and understanding of the contribution of vascular factors to neurological diseases, with a focus on Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA), so that we can minimize the risk and to develop treatments that specifically target brain vasculature function.

My research focuses on investigating the following:

  • Role of functional blood-brain barrier (BBB) in maintaining brain function and homeostasis
  • Role of vasculature in clearing brain waste products like amyloid-β
  • The neurovascular unit that works in concert to maintain a healthy brain
  • Targeting the BBB as a preventive and therapeutic approach to protect neurons
  • Discovery and development of drugs that target brain vasculature dysfunction in AD and CAA

 Book Chapters

Abuznait A, Qosa H, Mohamed LA, Batarshe YS, Kaddoumi A. “Neuroprotective effects of olive oil components in Alzheimer disease” in Neuroprotective Effects of Phytochemicals in Neurological disorders. Editors: Farooqui T, Farooqui AA. Wiley Blackwell. 2017.

Heimbach T., Fleisher D., Kaddoumi A., “Overcoming poor aqueous solubility of drugs for oral delivery” in Prodrugs: Challenges and rewards. Editors: Stella V., Borchardt R.T., Hageman M.J., Oliyai R., Tilley J.W., and Maag H. AAPS Press, Arlington, VA. Part 1, 2007; 157-216.

 Refereed Papers

Batarseh YS, Bharate SS, Kumar V, Kumar A, Vishwakarma RA, Bharate SB, Kaddoumi A. Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice. ACS Chem Neurosci. 2017; 8(8):1756-1766.

Batarseh YS, Mohamed LA, Al Rihani SB, Mousa YM, Siddique AB, El Sayed KA, Kaddoumi A. Oleocanthal ameliorates amyloid-β oligomers toxicity on astrocytes and neuronal cells: In-vitro studies.  Neuroscience 2017, 352:204-215.

Wang YJ, Zhang YK, Zhang GN, Al Rihani SB, Wei MN, Gupta P, Zhang XY, Shukla S, Ambudkar SV, Kaddoumi A, Shi Z, Chen ZS. Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study. Cancer Lett. 2017 2017; 396:145-154.

Kaddoumi A, Gill KK, Elfakhri K, Nazzal S. Development and qualification of an LC-MS/MS method for investigating the biological implications of micelle entrapped paclitaxel in cell culture and rats. Biomed Chromatogr. 2017; 31(9). doi: 10.1002/bmc.3960.

Wang YJ, Patel BA, Anreddy N, Zhang YK, Zhang GN, Alqahtani S, Singh S, Shukla S, Kaddoumi A, Ambudkar SV, Talele TT, Chen ZS. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Sci Rep. 2017. 7:42106. doi: 10.1038/srep42106.

Mohamed LA, Zhu H, Mousa YM, Wang E, Qiu WQ, Kaddoumi A. Amylin Enhances Amyloid-β Peptide Brain to Blood Efflux across the Blood-Brain Barrier. Journal of Alzheimer’s Dis. 2017; 56(3):1087-1099.

Gill KK, Kamal MM, Kaddoumi A, Nazzal S. EGFR targeted delivery of paclitaxel and parthenolide co-loaded in PEG-Phospholipid micelles enhance cytotoxicity and cellular uptake in non-small cell lung cancer cells. J Drug Deliv Sci Technol. 2016. 36:150-155.

Qosa H, Mohamed LA, Al Rihani SB, Batarseh YS, Duong QV, Keller JN, Kaddoumi A. High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity. J Alzheimers Dis. 2016;53(4):1499-516.

Qosa H, Mohamed LA, Alqahtani S, Abuasal BS, Hill RA, Kaddoumi A. Transporters as Drug Targets in Neurological Diseases. Clin Pharmacol Ther. 2016; 100(5):441-453.

Qosa H, Kaddoumi A. Effect of mouse strain as a background for Alzheimer's disease models on the clearance of amyloid-β. J Syst Integr Neurosci. 2016; 2(2):135-140.

Batarseh YS, Duong QV, Mousa YM, Al Rihani SB, Elfakhri K, Kaddoumi A. Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders. Int J Mol Sci. 2016;17(3):338. doi: 10.3390/ijms17030338.

Alqahtani S. Kaddoumi A. Development of PBPK/PD Model to Predict Impact of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics represented by receptor/transporter occupancy of CNS drugs. Clinical Pharmacokinetics. 2016;55(8):957-69.

Mohamed LA, Keller JN, Kaddoumi A. Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model. Biochim Biophys Acta. 2016;1862(4):778-87.

Alqahtani S, Kaddoumi A. Development of Physiologically Based Pharmacokinetic/ Pharmacodynamic Model for Indomethacin Disposition in Pregnancy. PLoS One. 2015; 10(10):e0139762. doi: 10.1371/journal.pone.0139762.

Qosa H, Batarseh YS, Mohyeldin MM, El Sayed KA, Keller JN, Kaddoumi A. Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model. ACS Chem Neurosci. 2015 ;6(11):1849-59.

Qosa H, Mohamed LA, Batarseh YS, Alqahtani S, Ibrahim B, LeVine H 3rd, Keller JN, Kaddoumi A. Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice. J Nutr Biochem. 2015; S0955-2863(15)00189-8.

Alqahtani S, Kaddoumi A. Development of a Physiologically Based Pharmacokinetic/ Pharmacodynamic Model to Identify Mechanisms Contributing to Entacapone Low Bioavailability. Biopharm Drug Dispos. 2015;36(9):587-602.

Abu-Fayyad A, Behery F, Sallam A, Alqahtani S, Ebrahim H, El Sayed KA, Kaddoumi A, Sylvester PW, Carroll JL, Cardelli JA, Nazzal S. PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability. Eur J Pharm Biopharm. 2015;96:185-95.

Alqahtani S, Qosa H, Primeaux B, Kaddoumi A. Orlistat limits cholesterol intestinal absorption by Niemann-pick C1-like 1 (NPC1L1) inhibition. Eur J Pharmacol. 2015; 762:263-9.

Kathawala RJ, Wang YJ, Shukla S, Zhang YK, Alqahtani S, Kaddoumi A, Ambudkar SV, Ashby CR Jr, Chen ZS. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chin J Cancer. 2015;34(1):5.

Mohamed LA, Qosa H, Kaddoumi A. Age-Related Decline in Brain and Hepatic Clearance of Amyloid-beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats. ACS Chem Neurosci. 2015 May 20;6(5):725-36.

Alqahtani S, Simon L, Astete CE, Alayoubi A, Sylvester PW, Nazzal S, Shen Y, Xu Z, Kaddoumi A, Sabliov CM. Cellular uptake, antioxidant and antiproliferative activity of entrapped α-tocopherol and γ-tocotrienol in poly (lactic-co-glycolic) acid (PLGA) and chitosan covered PLGA nanoparticles (PLGA-Chi). J Colloid Interface Sci. 2015;445:243-51.

Bharate JB, Batarseh YS, Wani A, Sharma S, Vishwakarma RA, Kaddoumi A, Kumar A, Bharate SB. Synthesis and P-glycoprotein induction activity of colupulone analogs. Org Biomol Chem. 2015;13(19):5488-96.

Gill KK, Kaddoumi A, Nazzal S. PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target. 2015;23(3):222-31.

<>Ayoub NM, Kaddoumi A. Obesity and Breast Cancer: Molecular and Epidemiological Evidence. J Cancer Res Updates. 2015;4(1):30-42.

Alqahtani S, Kaddoumi A. Vitamin E Transporters in Cancer Therapy. AAPS J. AAPS J. 2015;17(2):313-22.

Gill KK, Kaddoumi A, Nazzal S. PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target. 2015;23(3):222-31.

 

Last Updated: August 31, 2017