|Departments||Student Services||Alumni||Research||Outreach||Graduate Students|
|Rita M. Graze|
Postdoctoral Fellow - University of Florida, Molecular Genetics and Microbiology
My research addresses functional genomic, quantitative genetic and evolutionary questions, with a focus on the role of gene regulation. These research areas inform one another. Functional genomic studies help us understand how the links between genotype and phenotype shape variability within species and the evolution of species differences. Conversely, by studying genetic variation in complex traits within populations and in different species, we are better able to build predictive genotype to phenotype maps for these traits. I use Drosophila as a model system and a variety of transgenic and genomic experimental techniques, as well as statistical and bioinformatics analyses, are employed.
Graze, R. M., McIntyre, L.M., Morse, A.M., Boyd, B.M., Nuzhdin, S.V., and Wayne, M.L. 2014. What the X has to do with it: differences in regulatory variability between the sexes in Drosophila simulans. Genome Biology and Evolution (in press) doi: 10.1093/gbe/evu060
Jensen, K., Sanchez-Garcia, J., Williams, C., Khare, S., Mathur, K., Graze, R. M., et al. 2013. Purification Of Transcripts And Metabolites From Drosophila Heads. J. Vis. Exp., 15;(73):e50245. doi: 10.3791/50245.
Graze, R.M., Novelo, L.L., Amin, V., Fear, J. M., Casella, G., Nuzhdin, S.V., and McIntyre, L.M. 2012. Allelic imbalance in Drosophila hybrid heads: exons, isoforms and evolution. Mol Biol Evol. First published online January 7 doi: 10.1093/molbev/msr318.
Yang, Y., Graze, R.M., Walts, B.M., Lopez, C.M., Baker, H.V., Wayne, M.L., Nuzhdin, S.V., and McIntyre, L.M. 2011. Partitioning Transcript Variation in Drosophila: Abundance, Isoforms and Alleles. G3 1:427-436.
Graze, R.M., McIntyre, L.M., Main, B.J., Wayne, M.L., and Nuzhdin, S.V. 2009. Regulatory divergence in Drosophila melanogaster and D. simulans, a genome-wide analysis of allele specific expression. Genetics 183:547-561.
Main, B.J., Bickel, R.D., McIntyre, L.M., Graze, R.M., Calabrase, P.P., and Nuzhdin, S.V. 2009. Allele-specific expression assays using Solexa. BMC Genomics 10:422.
Graze, R.M., Barmina, O., Tufts, D., Naderi, E., Harmon, K.L., Persianinova, M., and Nuzhdin, S.V. 2007. New candidate genes for sex comb divergence between Drosophila mauritiana and Drosophila simulans. Genetics 176: 2561–2576.
Kopp, A., Graze, R.M., Xu, S., Carroll, S.B. and Nuzhdin, S.V. 2003. Quantitative Trait Loci Responsible for Variation in Sexually Dimorphic Traits in Drosophila melanogaster. Genetics 163: 771-787.