Paul A. Cobine
Associate Professor

Office: 325 Rouse Life Sciences Bldg.

Address:
101 Rouse Life Sciences Bldg.
Auburn University, AL 36849

Office Phone: (334) 844-1661
Email Paul A. Cobine

Lab/Research Page

Education

Postdoctoral Fellow - University of Utah 2007
Ph.D. - The University of Queensland, Australia 2004
B.S. - The University of Queensland, Australia 1996


Research and Teaching Interests

My research is focused on the mechanisms for recruitment and distribution of metals. Metal availability is a limiting factor for cell survival, therefore mechanisms to maintain the appropriate metal concentration have been highly conserved. We are especially interested in 1) how metals are distributed, stored and used in mitochondria; the majority of these studies use the model organism Saccharomyces cerevisiae and 2) the metal requirements of the phytopathogen Xylella fastidiosa in infection and the subsequent development of disease.


Selected Publications

Click link for citation report on Paul Cobine on Google Scholar

Zhiyuan Ge, James D. Johnson, Paul A. Cobine, Kevin J. McGraw, Rosana Garcia, Geoffrey E. Hill (2015) High Concentrations of Ketocarotenoids in Hepatic Mitochondria of Haemorhous mexicanus. Physiol Biochem Zool. 88(4):444-50

Jonathan E. Oliver, Paul A. Cobine, Leonardo De La Fuente (2015) Xylella fastidiosa Isolates from Both subsp. multiplex and fastidiosa Cause Disease on Southern Highbush Blueberry (Vaccinium sp.) Under Greenhouse Conditions. Phytopathology. Jul;105(7):855-62

Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T, Hossain A, El Zawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT, Viswanathan D, Petris MJ, Leary SC. (2015) The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. Cell Rep. pii: S2211-1247(15)00032-7.

Luisa F. Cruz, Jennifer K. Parker, Paul A. Cobine, Leonardo De La Fuente (2014)  Calcium-Enhanced Twitching Motility in Xylella fastidiosa Is Linked to a Single PilY1 Homolog.  Appl Environ Microbiol. 80(23):7176-85.

Jonathan E. Oliver, Stephen A. Sefick, Jennifer K. Parker, Travis Arnold, Paul A.  Cobine, Leonardo De La Fuente (2014) Ionome changes in Xylella fastidiosa-infected Nicotiana tabacum correlate with virulence and discriminate between subspecies of bacterial isolates. Mol Plant Microbe Interact. 27(10):1048-58. 

Katherine E. Vest, Scot C. Leary, Dennis R. Winge, and Paul A. Cobine (2013)” Copper Import into the Mitochondrial Matrix in Saccharomyces cerevisiae is Mediated by Pic2, a Mitochondrial Carrier Family Protein” Journal of Biological Chemistry, doi:10.1074/jbc.M113.470674 

Scot C. Leary, Hana Antonicka, Florin Sasarman, Woranontee Weraarpachai, Paul A. Cobine, Min Pan, Garry K. Brown, Ruth Brown, Jacek Majewski, Jeremy Swartzentruber, Shamima Rahman, and Eric Shoubridge  (2013) “Novel mutations in SCO1 as a cause of fatal infantile encephalopathy and lactic acidosis” Human Mutations, 34(10):1366-70 

Leonardo De La Fuente, Jennifer Parker, Jonathan E. Oliver, Shea Granger, Edzard Van Santen and Paul A. Cobine (2013) “The Bacterial Pathogen Xylella fastidiosa Affects the Leaf Ionome of Plant Hosts during Infection” PLoS ONE, 8(5): e62945 31  

Katherine E. Vest, Paul A. Cobine, (2013) "Copper in Mitochondria ", Encyclopedia of Inorganic and Bioinorganic Chemistry, John Wiley and Sons, Eds: Robert Scott and Valeria Culotta. 

Dorothy J. Cheruiyot, Robert S. Boyd, Thomas A. Coudron and Paul A. Cobine (2013) “Biotransfer, bioaccumulation and effects of herbivore dietary Co, Cu, Ni and Zn on growth and development of the insect predator Podisus maculiventris (Say) (Hemiptera: Pentatomidae)” Journal of Chemical Ecology, 39(6):764-72.

Leonardo De La Fuente, Luisa Cruz, Fernando Navarrete, Jonathan Oliver, Paul A. Cobine (2013) “Metal elements as regulators of virulence in plant pathogenic bacteria” Virulence Mechanisms of Plant Pathogenic Bacteria, APS Press.

John D. Peterson, John E. Steffen, Laura K. Reinert, Paul A. Cobine, Arthur Appel, Louise A Rollins‐Smith, Mary T. Mendonca (2013) “The pathogenesis of the deadly amphibian disease, chytridiomycosis, suggests development of a stress response” PLoS ONE 8(4): e62146 31

Scot C. Leary, Paul A. Cobine, Tamiko Nishimura, Robert M. Verdijk, Ronald de Krijger, René de Coo, Mark A. Tarnopolsky, Dennis R. Winge and Eric A. Shoubridge (2013) COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A‐mediated cellular copper efflux” Molecular Biology of the Cell, 24(6):683‐91

Paul A. Cobine, Luisa Cruz, Fernando Navrette, Daniel Duncan, Melissa Tygart and Leonardo De La Fuente (2013) “Xylella fastidiosa differentially accumulates mineral elements as biofilm and planktonic cells” PLoS ONE 8(1):e54936 31

K.E. Vest, H.F. Hashemi and P.A. Cobine (2013) “Copper Metallome in Eukaryotic cells” Metal Ions in Life Sci.,12:451-71



Courses

Undergraduate Graduate
General Microbiology - BIOL3200



Last updated: 01/08/2016