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|Paul A. Cobine|
Postdoctoral Fellow - University of Utah (2007)
My research is focused on the mechanisms for recruitment and distribution of metals. Metal availability is a limiting factor for cell survival, therefore mechanisms to maintain the appropriate metal concentration have been highly conserved. We are especially interested in 1) how metals are distributed, stored and used in mitochondria; the majority of these studies use the model organism Saccharomyces cerevisiae and 2) the metal requirements of the phytopathogen Xylella fastidiosa in infection and the subsequent development of disease. Generally our studies combine direct metal-binding analysis with assessment of physiological outcomes, using protein chemistry, spectroscopy and genetics. I teach the fundamentals of microbiology in General Microbiology and special topics classes on Molecular Basis of Disease or Environmental Toxicology of Metals.
L. De La Fuente, J. Parker, J.E. Oliver, S. Granger, E. Van Santen and P.A. Cobine (2013) “The Bacterial Pathogen Xylella fastidiosa Affects the Leaf Ionome of Plant Hosts during Infection” PLoS ONE, 8(5):e62945 31
K.E. Vest, P.A. Cobine, (2013) "Copper in Mitochondria", Encyclopedia of Inorganic and Bioinorganic Chemistry, in press.
D.J. Cheruiyot, R.S. Boyd, T.A. Coudron and P.A. Cobine (2013) “Biotransfer, bioaccumulation and effects of herbivore dietary Co, Cu, Ni and Zn on growth and development of the insect predator Podisus maculiventris (Say) (Hemiptera: Pentatomidae)” J. Chem. Ecol., in press
J.D. Peterson, J.E. Steffen, L.K. Reinert, P.A. Cobine, A. Appel, L.A. Rollins‐Smith, M.T. Mendonca (2013) “The pathogenesis of the deadly amphibian disease, chytridiomycosis, suggests development of a stress response” PLoS ONE 8(4):e62146 31
S.C. Leary, P.A. Cobine, T. Nishimura, R.M. Verdijk, R. de Krijger, R. de Coo, M.A. Tarnopolsky, D.R. Winge and E.A. Shoubridge (2013) “COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A‐mediated cellular copper efflux” Mol. Biol. Cell, 24(6):683‐91
P.A. Cobine, L. Cruz, F. Navrette, D. Duncan, M. Tygart and L. De La Fuente (2013) “Xylella fastidiosa differentially accumulates mineral elements as biofilm and planktonic cells” PLoS ONE 8(1):e54936 31
K.E. Vest, H.F. Hashemi and P.A. Cobine (2013) “Copper Metallome in Eukaryotic cells” Metal Ions in Life Sci., 12:451-71
L. Cruz, P.A. Cobine and L. De La Fuente (2012) “Calcium increases surface attachment, biofilm formation, and twitching motility in Xylella fastidiosa” Appl. Environ. Micro. 78(5):1321‐31
S.C. Dodani, S.C. Leary, P.A. Cobine, D.R. Winge, and C.J. Chang (2011) “A Targetable Fluorescent Sensor Reveals that Copper‐Deficient SCO1 and SCO2 Patient Cells Prioritize Mitochondrial Copper Homeostasis” J. Am. Chem. Soc., 133(22): 8606‐16.