Hepatic Physiology
  1. Introduction
    1. General description & circulatory supply
    2. Functional Overview
  2. Anatomy
    1. Lobule
    2. Microanatomy - See Figure
    3. Blood Flow
      1. Anatomy
      2. Dynamics & Pressures
  3. Liver - Gall Bladder - Duodenum - Relationships
    1. Release of Bile
      1. Cholecystokinin
      2. VagalStimulation
      3. Bile Salts
  4. Constituents of Bile
    1. Bilirubin - See R.B.C. notes
    2. Bile Salts
      1. Formation
      2. Function in Fat Digestion
        1. Emulsification
        2. Micelle formation
      3. Fate of Bile Salts
    3. Cholesterol
      1. Function
      2. Gall Stones
  5. Metabolic Functions of the Liver
    1. CHO 's
      1. Metabolism of monosaccharides
      2. Gluconeogenesis
      3. Glycogen metabolism
    2. Protein Metabolism
      1. Plasma Protein Synthesis
      2. Transamination
      3. Urea Synthesis
    3. Lipid Metabolism
      1. Synthesis of lipoproteins
        1. Types
          • Chylomicrons
          • VLDL's
          • LDL's and HDL's
        2. Application in cholesterol biology
      2. Synthesis of cholesterol
      3. Synthesis of lipoproteins
      4. Hypolipemic drugs
        1. Cholestyramine (Questran)
        2. Gemfibrozil (Lopid)
        3. Lovastatin (Mevacor)
  6. Storage by Liver
  7. Detoxification by Liver
  8. Modulate Hormone Action
  9. IX. Role of Liver in Coagulation and Hemostasis
    1. Vascular spasm
    2. Formation of the platelet plug
    3. Coagulation
      1. Formation of prothrombin activator
      2. Conversion of prothrombin to thrombin
      3. Conversion of fibrinogen to fibrin
      4. Fate of Clot
  10. Anticoagulants and Fibrinolytic Drugs
    1. Anticoagulants
      1. Heparin sodium (Liquaemin)
      2. Heparin calcium (Calciparine)
      3. Heparin sodium + Dihydroergotamine mesylate (Embolex)
      4. Warfarin (Carfin, Coumadin)
      5. Citrates and oxylates
    2. Fibrinolytic drugs
      1. Streptokinase (Streptase)
      2. Alteplace (Activase)
  11. Pathologies
    1. Hepatitis
    2. Hemophilia
    3. Thrombus & Embolus
    4. Disseminated Intravascular Clotting
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