Reading and related information for Example test 1 for ZY 561
1. Define renal clearance
2. Calculate the renal clearance of substance X given the following information:
- Urine volume = 8 ml/min
- Hematocrit = 50
- Tmax of X = 200 mg/min
- Plasma concentration of X = 0.02 mg/ml
- Filtration fraction = 25%
- Urine concentration of X = 5 mg/ml
- Inulin clearance = 140
3. Calculate the GFR given the following:
- Cardiac output = 5000 ml/min
- Filtration fraction = 20%
- Tmax (glucose) = 400 mg/min
- Renal fraction = 25%
- T-Load (glucose) = 200 mg/min
- Creatinine clearance = 140
- Renal clearance of glucose = 0
4. Calculate the tubular load of glucose given the following:
- Urine volume = 2 ml/min
- Glucose concentration in urine = 0.1 mg/ml
- Plasma concentration of glucose = 2 mg/ml
- Renal clearance PAH = 1000
- Renal fraction = 20%
- Filtration fraction = 25%
- Hematocrit = 50
5. Calculate the renal plasma threshold of substance Z given the following information:
- Hematocrit = 50
- Tmax of substance Z = 300 mg/min
- Renal fraction = 20%
- Urine volume = 6 ml/min
- Urine concentration of Z = 3 mg/ml
- GFR = 100 ml/min
- Plasma concentration of Z = 6 mg/ml
6. Suppose line X represents the amount of inulin that is filtered
- Draw a line labeled Y to indicate the amount of inulin excreted
- Draw a line labeled Z to indicate the amount of fibrinogen that is filtered
- Draw a line labeled Q to indicate the amount of glucose in the efferent arteriole
- Draw a line labeled P to indicate the amount of PAH that is filtered
In 25 words or less explain why (mechanism) drugs like Lasix are referred to as hi-ceiling diuretics