Our main research interests lie within the overlapping fields of RNA structure and function, protein-nucleic acid interactions, and protein synthesis. The work is concentrated on tRNA and tmRNA, two small RNA molecules which play an important role in protein synthesis and trans-translation.Dr. Jacek Wower
Associate Professor of Biochemistry
Program in Cell and Molecular Biosciences
Department of Animal and Dairy Sciences
209 Upchurch Hall
Auburn University
Auburn, AL 36849-5415Tel: (334) 844-1508 (office) or (334) 844-1554 (lab)
Fax: (334) 844-1519
e-mail: jwower@acesag.auburn.edu
Research
Sylvers, L.A., and Wower, J. (1993) Nucleic Acid-Incorporated Azidonucleotides: Probes for Studying the Interaction of RNA or DNA with Proteins and other Nucleic Acids, Bioconjugate Chemistry 4, 411-418.Recent Publications (selected)
Wower, J., Scheffer, P., Sylvers, L.A., Wintermeyer, W. and Zimmermann, R.A. (1993) Identification of Ribosomal Components at the Ribosomal E site by Cross-linking to Photoreactive tRNAPhe Derivatives, EMBO J. 12(2), 617-623.
Wower, J., Rosen, K.V., Hixson, S.S., and Zimmermann, R.A. (1994) Recombinant Photoreactive tRNA Molecules as Probes for Cross-linking Studies, Biochimie 76, 1235-1246.
Wower, J., Wower, I.K., Kirillov, S., Rosen, K., Hixson, S.S. and Zimmermann, R.A. (1996) Peptidyl Transferase and Beyond. Biochemistry and Cell Biology 73, 1041-1047.
Wower, I., Wower, J. and Zimmermann, R.A. (1997) The Role of Protein L27 in the Assembly and Function of the Escherichia coli Ribosome, Proc. Natl. Acad. Sci. USA. 273, 19847-19852.
Wower, J. and C. Zwieb (1999) The tmRNA database (tmRDB). Nucleic Acids Res. 27(1):167.
C. Zwieb, I. Wower, and J. Wower (1999) Comparative sequence analysis of tmRNA. Nucleic Acids Res. 27(10): 2063-2071.
J. Wower, C. Zwieb, and I. Wower (2000) tmRNA: A Case of Structural and Functional Mimicry on and off the Ribosome. In: The Ribosome (R. A. Garrett, ed.), ASM Press, in press.
Kirillov, S.V., Wower, J., Hixsson, S.S. and Zimmermann, R.A. (1999) Transit of tRNA through the Escherichia coli ribosome: Cross-linking the 3í of tRNA to Specific Nucleotides of the 23S Ribosomal RNA at the A, P and E sites. (J. Mol. Biol., submitted).
tmRNA database (Auburn University/mirror site)
tmRNA database (University of Texas Health Center at Tyler, TX)
Other useful links
The
tmRNA Website
The RNA Society
Courses Taught
Biochemistry (ANSC 618; 5h; Fall) Classification,
structure and chemistry of the major chemical constituents of living matter
Proteins (ANSC 741; 5h; Spring) Chemical and physical
properties of amino acids and proteins, protein structures and the relation
of protein structure to function
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